| Literature DB >> 31767267 |
Kaitlin Kiernan1, Nancie J MacIver2.
Abstract
In their recent study, Nicholas et al. challenge the current dogma that T cell inflammation must be fueled by glycolysis and demonstrate a novel metabolic mechanism for Th17 inflammation in human type 2 diabetes mellitus (T2DM): a combination of increased environmental long-chain fatty acid metabolites coupled with decreased fatty acid oxidation.Entities:
Keywords: Th17; fatty acid oxidation; metabolism; obesity; type 2 diabetes
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Year: 2019 PMID： 31767267 DOI： 10.1016/j.tem.2019.11.002
Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015