Susanne Schulz1, Axel Schlitt2,3, Britt Hofmann4, Hans-Günter Schaller1, Stefan Reichert1. 1. Department of Operative Dentistry and Periodontology, Martin Luther-University Halle-Wittenberg, Halle (Saale), Germany. 2. Department of Internal Medicine III, Heart Centre of the University Clinics Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany. 3. Department of Cardiology, Paracelsus Harz-Clinic Bad Suderode, Quedlinburg, Germany. 4. Department of Cardiothoracic Surgery, Heart Centre of the University Clinics Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Abstract
AIM: Periodontitis has been identified as a moderate but independent risk factor for cardiovascular (CV) disease and progression. The objective of this study (ClinicalTrials.gov Identifier: NCT01045070) was to assess subgingival colonization with selected periodontal pathogens on the occurrence of further adverse CV events in a cohort of CV patients. METHODS: The prevalence of severe periodontitis including the detection of 11 periodontal pathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, Treponema denticola, P. intermdia, Peptostreptococcus micros, Fusobacterium nucleatum, Campylobacter rectus, Eubacterium nodatum, Eikenella corrodens, Capnocytophaga sputigena, Capnocytophaga gingivalis, Capnocytophaga ochracea; HAIN-Diagnostica® ) was analysed in 1,002 CV patients The prognostic impact of periodontal pathogens for combined CV endpoint (stroke/TIA, myocardial infarction, CV death, death from stroke) was evaluated after a 3-year follow-up period. Hazard ratios (HRs) were adjusted for established CV risk factors applying Cox regression. RESULTS: In the Kaplan-Meier analysis (log-rank test: p < .001) and Cox regression (HR: 0.545, 95%-CI: 0.387-0.773; p = .001), the decreased occurrence of E. corrodens was shown to be an independent predictor for adverse CV events after 3 years of follow-up. CONCLUSIONS: The detection of E. corrodens was associated with a reduced risk of adverse CV events in patients with CV disease. The pathophysiological background underlying this association should be investigated in further studies.
AIM: Periodontitis has been identified as a moderate but independent risk factor for cardiovascular (CV) disease and progression. The objective of this study (ClinicalTrials.gov Identifier: NCT01045070) was to assess subgingival colonization with selected periodontal pathogens on the occurrence of further adverse CV events in a cohort of CV patients. METHODS: The prevalence of severe periodontitis including the detection of 11 periodontal pathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, Treponema denticola, P. intermdia, Peptostreptococcus micros, Fusobacterium nucleatum, Campylobacter rectus, Eubacterium nodatum, Eikenella corrodens, Capnocytophaga sputigena, Capnocytophaga gingivalis, Capnocytophaga ochracea; HAIN-Diagnostica® ) was analysed in 1,002 CV patients The prognostic impact of periodontal pathogens for combined CV endpoint (stroke/TIA, myocardial infarction, CV death, death from stroke) was evaluated after a 3-year follow-up period. Hazard ratios (HRs) were adjusted for established CV risk factors applying Cox regression. RESULTS: In the Kaplan-Meier analysis (log-rank test: p < .001) and Cox regression (HR: 0.545, 95%-CI: 0.387-0.773; p = .001), the decreased occurrence of E. corrodens was shown to be an independent predictor for adverse CV events after 3 years of follow-up. CONCLUSIONS: The detection of E. corrodens was associated with a reduced risk of adverse CV events in patients with CV disease. The pathophysiological background underlying this association should be investigated in further studies.
Authors: Tania Seoane; Beatriz Bullon; Patricia Fernandez-Riejos; Juan Carlos Garcia-Rubira; Nestor Garcia-Gonzalez; Pablo Villar-Calle; Jose Luis Quiles; Maurizio Battino; Pedro Bullon Journal: J Clin Med Date: 2022-05-06 Impact factor: 4.964
Authors: Susanne Schulz; Britt Hofmann; Julia Grollmitz; Lisa Friebe; Michael Kohnert; Hans-Günter Schaller; Stefan Reichert Journal: Biomedicines Date: 2022-07-27
Authors: Nicole Jacobi; Carolin Walther; Katrin Borof; Guido Heydecke; Udo Seedorf; Ragna Lamprecht; Thomas Beikler; Sebastian E Debus; Christoph Waldeyer; Stefan Blankenberg; Renate B Schnabel; Ghazal Aarabi; Christian-Alexander Behrendt Journal: J Clin Med Date: 2021-05-11 Impact factor: 4.241