Christina Nieuwoudt1, Angela Brooks-Wilson2,3, Jinko Graham1. 1. Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, BC V5A 1S6. 2. Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC V5Z 1L3. 3. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Abstract
SUMMARY: We present the R package SimRVSequences to simulate sequence data for pedigrees. SimRVSequences allows for simulations of large numbers of single-nucleotide variants (SNVs) and scales well with increasing numbers of pedigrees. Users provide a sample of pedigrees and SNV data from a sample of unrelated individuals. AVAILABILITY AND IMPLEMENTATION: SimRVSequences is publicly-available on CRAN https://cran.r-project.org/web/packages/SimRVSequences/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
SUMMARY: We present the R package SimRVSequences to simulate sequence data for pedigrees. SimRVSequences allows for simulations of large numbers of single-nucleotide variants (SNVs) and scales well with increasing numbers of pedigrees. Users provide a sample of pedigrees and SNV data from a sample of unrelated individuals. AVAILABILITY AND IMPLEMENTATION: SimRVSequences is publicly-available on CRAN https://cran.r-project.org/web/packages/SimRVSequences/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Authors: R Tanzi; S Gaston; A Bush; D Romano; W Pettingell; J Peppercorn; M Paradis; S Gurubhagavatula; B Jenkins; W Wasco Journal: Genetica Date: 1993 Impact factor: 1.082
Authors: Gonçalo R Abecasis; David Altshuler; Adam Auton; Lisa D Brooks; Richard M Durbin; Richard A Gibbs; Matt E Hurles; Gil A McVean Journal: Nature Date: 2010-10-28 Impact factor: 49.962