Michael J Joyner1, Nigel Paneth2,3. 1. Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota. 2. Departments of Epidemiology and Biostatistics, Michigan State University, College of Human Medicine, East Lansing. 3. Departments of Pediatrics and Human Development, Michigan State University, College of Human Medicine, East Lansing.