Literature DB >> 31763684

Poor survival after resection of early gastric cancer: extremes of survivorship analysis reveal distinct genomic profile.

J Datta1,2, E M Da Silva3, C Kandoth4, T Song4, A E Russo1, J M Hernandez1,5, B S Taylor4, Y Y Janjigian6, L H Tang3, D B Solit6,4, V E Strong1.   

Abstract

A subset of patients with early gastric cancer demonstrate early recurrence and poor survival despite margin-negative resection. This study used an extremes-of-survivorship approach to identify an association between TP53 hotspot mutations co-occurring with loss of heterozygosity and unexpectedly poor survival in early gastric cancer. This distinct genomic profile may be a novel biomarker of poor survival in patients with completely resected early gastric cancer, and warrants large-scale validation. Promising, validation needed.
© 2019 BJS Society Ltd Published by John Wiley & Sons Ltd.

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Year:  2019        PMID： 31763684      PMCID： PMC7453628          DOI： 10.1002/bjs.11443

Source DB:  PubMed          Journal:  Br J Surg        ISSN： 0007-1323            Impact factor:   6.939


  12 in total

1.  An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus.

Authors:  G C DeLuca; S V Ramagopalan; B M Herrera; D A Dyment; M R Lincoln; A Montpetit; M Pugliatti; M C N Barnardo; N J Risch; A D Sadovnick; M Chao; S Sotgiu; T J Hudson; G C Ebers
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-17       Impact factor: 11.205

2.  Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer.

Authors:  Yelena Y Janjigian; Francisco Sanchez-Vega; Philip Jonsson; Walid K Chatila; Jaclyn F Hechtman; Geoffrey Y Ku; Jamie C Riches; Yaelle Tuvy; Ritika Kundra; Nancy Bouvier; Efsevia Vakiani; Jianjiong Gao; Zachary J Heins; Benjamin E Gross; David P Kelsen; Liying Zhang; Vivian E Strong; Mark Schattner; Hans Gerdes; Daniel G Coit; Manjit Bains; Zsofia K Stadler; Valerie W Rusch; David R Jones; Daniela Molena; Jinru Shia; Mark E Robson; Marinela Capanu; Sumit Middha; Ahmet Zehir; David M Hyman; Maurizio Scaltriti; Marc Ladanyi; Neal Rosen; David H Ilson; Michael F Berger; Laura Tang; Barry S Taylor; David B Solit; Nikolaus Schultz
Journal:  Cancer Discov       Date:  2017-11-09       Impact factor: 39.397

3.  Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology.

Authors:  Donavan T Cheng; Talia N Mitchell; Ahmet Zehir; Ronak H Shah; Ryma Benayed; Aijazuddin Syed; Raghu Chandramohan; Zhen Yu Liu; Helen H Won; Sasinya N Scott; A Rose Brannon; Catherine O'Reilly; Justyna Sadowska; Jacklyn Casanova; Angela Yannes; Jaclyn F Hechtman; Jinjuan Yao; Wei Song; Dara S Ross; Alifya Oultache; Snjezana Dogan; Laetitia Borsu; Meera Hameed; Khedoudja Nafa; Maria E Arcila; Marc Ladanyi; Michael F Berger
Journal:  J Mol Diagn       Date:  2015-03-20       Impact factor: 5.568

4.  LOH in the HLA class I region at 6p21 is associated with shorter survival in newly diagnosed adult glioblastoma.

Authors:  Jacky T Yeung; Ronald L Hamilton; Koji Ohnishi; Maki Ikeura; Douglas M Potter; Marina N Nikiforova; Soldano Ferrone; Regina I Jakacki; Ian F Pollack; Hideho Okada
Journal:  Clin Cancer Res       Date:  2013-02-11       Impact factor: 12.531

5.  Risk factors for recurrence in T1-2N0 gastric cancer in the United States and China.

Authors:  Liang Cao; Luke V Selby; Xiang Hu; Yi Zhang; Yelena Y Janjigian; Laura Tang; Daniel G Coit; Murray F Brennan; Vivian E Strong
Journal:  J Surg Oncol       Date:  2016-04-04       Impact factor: 3.454

6.  Effects of TP53 mutational status on gene expression patterns across 10 human cancer types.

Authors:  Neha Parikh; Susan Hilsenbeck; Chad J Creighton; Tajhal Dayaram; Ryan Shuck; Eve Shinbrot; Liu Xi; Richard A Gibbs; David A Wheeler; Lawrence A Donehower
Journal:  J Pathol       Date:  2014-01-29       Impact factor: 7.996

7.  MSIsensor: microsatellite instability detection using paired tumor-normal sequence data.

Authors:  Beifang Niu; Kai Ye; Qunyuan Zhang; Charles Lu; Mingchao Xie; Michael D McLellan; Michael C Wendl; Li Ding
Journal:  Bioinformatics       Date:  2013-12-25       Impact factor: 6.937

8.  FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma.

Authors:  Krittiya Korphaisarn; Van Karlyle Morris; Michael J Overman; David R Fogelman; Bryan K Kee; Kanwal Pratap Singh Raghav; Shanequa Manuel; Imad Shureiqi; Robert A Wolff; Cathy Eng; David Menter; Stanley R Hamilton; Scott Kopetz; Arvind Dasari
Journal:  Oncotarget       Date:  2017-06-13

9.  p53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo.

Authors:  Evguenia M Alexandrova; Safia A Mirza; Sulan Xu; Ramona Schulz-Heddergott; Natalia D Marchenko; Ute M Moll
Journal:  Cell Death Dis       Date:  2017-03-09       Impact factor: 8.469

10.  Comprehensive molecular characterization of gastric adenocarcinoma.

Authors: 
Journal:  Nature       Date:  2014-07-23       Impact factor: 49.962
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  7 in total

1.  LncRNA PROX1-AS1 Facilitates Gastric Cancer Progression via miR-877-5p/PD-L1 Axis.

Authors:  TianWei Guo; Wei Wang; YueXia Ji; Min Zhang; GuoYing Xu; Sen Lin
Journal:  Cancer Manag Res       Date:  2021-03-19       Impact factor: 3.989

2.  Oxidative stress activates NORAD expression by H3K27ac and promotes oxaliplatin resistance in gastric cancer by enhancing autophagy flux via targeting the miR-433-3p.

Authors:  Jizhao Wang; Yuchen Sun; Xing Zhang; Hui Cai; Cheng Zhang; Hangying Qu; Lin Liu; Mingxin Zhang; Junke Fu; Jia Zhang; Jiansheng Wang; Guangjian Zhang
Journal:  Cell Death Dis       Date:  2021-01-18       Impact factor: 8.469

3.  A clinical study on the efficacy of Yiqi Huayu Jiedu decoction for reducing the risk of postoperative recurrence and metastasis of gastric cancer: Protocol for a multicenter, randomized, double-blind, placebo-controlled trial.

Authors:  Cun-En Wu; Wei-Wei Xue; Yu-Wen Zhuang; Da-Wei Ding; Jin-Yong Zhou; Shen-Lin Liu; Rui-Ping Wang; Peng Shu
Journal:  Medicine (Baltimore)       Date:  2020-11-25       Impact factor: 1.889

4.  Ras-p53 genomic cooperativity as a model to investigate mechanisms of innate immune regulation in gastrointestinal cancers.

Authors:  Austin R Dosch; Walid K Chatila; Yuguang Ban; Anna Bianchi; Nilesh U Deshpande; Iago De Castro Silva; Nipun B Merchant; Jashodeep Datta
Journal:  Oncotarget       Date:  2021-09-28

5.  Long non-coding RNA ZNF674-AS1 antagonizes oxaliplatin resistance of gastric cancer via regulating EZH2-mediated methylation of CHST7.

Authors:  Kun Ye; Yong Wang
Journal:  Aging (Albany NY)       Date:  2022-07-08       Impact factor: 5.955

6.  Early Gastric Cancer: identification of molecular markers able to distinguish submucosa-penetrating lesions with different prognosis.

Authors:  Paola Ulivi; Luca Saragoni; Chiara Molinari; Gianluca Tedaldi; Francesca Rebuzzi; Paolo Morgagni; Laura Capelli; Sara Ravaioli; Maria Maddalena Tumedei; Emanuela Scarpi; Anna Tomezzoli; Riccardo Bernasconi; Maria Raffaella Ambrosio; Alessia D'Ignazio; Leonardo Solaini; Francesco Limarzi; Giorgio Ercolani; Giovanni Martinelli
Journal:  Gastric Cancer       Date:  2020-11-06       Impact factor: 7.370

7.  Deciphering high risk molecular alterations in gastrointestinal malignancy utilizing an extreme outlier strategy.

Authors:  Austin R Dosch; Siddharth Mehra; Nipun B Merchant; Jashodeep Datta
Journal:  Oncoscience       Date:  2020-05-05
  7 in total

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