Literature DB >> 31762839

A case of pheochromocytoma presenting with cardiopulmonary arrest.

Takashi Touma1, Takafumi Miyara1, Yoji Taba1.   

Abstract

A 33-year-old woman complained of sudden chest pain and intense headache. She was unconscious and underwent defibrillation for ventricular fibrillation in the ambulance. In the emergency room, she was placed on an artificial respirator. Diffuse wall hypokinesis and decreased left ventricular ejection fraction (31%) were identified on transthoracic echocardiography, and an intra-aortic balloon pump was inserted to address the cardiogenic shock. A mass was identified in the right adrenal gland on abdominal ultrasonography. Since a pheochromocytoma was suspected, doxazosin and carvedilol were administered. Blood and urinary norepinephrine and dopamine levels were elevated, confirming the pheochromocytoma diagnosis, and right adrenalectomy was performed 23 days after the initial hospitalization. After surgery, the left ventricular wall motion and left ventricular ejection fraction had improved to 62% on echocardiography. Blood and urinary norepinephrine and dopamine levels also decreased to within the normal range. This case highlights that the patient returned to normalcy and recovered to a transient myocardial disorder or malignant arrhythmia after cardiopulmonary arrest due to early diagnosis of and accurate treatment for pheochromocytoma. <Learning objective: Pheochromocytomas secrete excessive levels of catecholamines that may cause cardiac dysfunction, including fatal arrhythmias. It is necessary for the transient hypertension and fatal arrhythmia appearance to consider the possibility of pheochromocytoma. The decreased cardiac function may be reversible with resection of the tumor. Therefore, early diagnosis and treatment can be lifesaving in such cases. Pheochromocytomas provide an interesting model to evaluate the vulnerability of the myocardium to adrenergic stimulation, such as in cases of takotsubo cardiomyopathy or catecholamine-induced cardiomyopathy.>.
© 2019 Published by Elsevier Ltd on behalf of Japanese College of Cardiology.

Entities:  

Keywords:  Left ventricular dysfunction; Pheochromocytoma; Ventricular fibrillation

Year:  2019        PMID: 31762839      PMCID: PMC6859743          DOI: 10.1016/j.jccase.2019.08.009

Source DB:  PubMed          Journal:  J Cardiol Cases        ISSN: 1878-5409


  10 in total

1.  Recurrent ventricular tachycardia in malignant metastatic pheochromocytoma.

Authors:  Ji Won Park; Seung Jung Park; Kyu Yeon Hur; Jung Han Kim; Yoon La Choi; Sun Mi Park; Sung Min Kim; Eun Hee Koo; June Soo Kim
Journal:  Circulation       Date:  2012-03-13       Impact factor: 29.690

Review 2.  Phaeochromocytoma.

Authors:  Jacques W M Lenders; Graeme Eisenhofer; Massimo Mannelli; Karel Pacak
Journal:  Lancet       Date:  2005 Aug 20-26       Impact factor: 79.321

3.  Images in cardiovascular medicine. Pheochromocytoma-related cardiomyopathy: inverted Takotsubo contractile pattern.

Authors:  Angel Sanchez-Recalde; Olga Costero; José M Oliver; Cristian Iborra; Elena Ruiz; José A Sobrino
Journal:  Circulation       Date:  2006-05-02       Impact factor: 29.690

4.  Sudden cardiac arrest after minor abdominal trauma: a successful resuscitation in a patient with haemorrhagic phaeochromocytoma.

Authors:  Chun-Chieh Chiu; Ying-Cheng Chen; Tsung-Han Teng; Li-Heng Yang; Ya-Pei Chen; Fu-Yuan Siao
Journal:  Resuscitation       Date:  2009-08-26       Impact factor: 5.262

5.  Severe dilated cardiomyopathy after propranolol treatment in an undiagnosed adrenal pheochromocytoma.

Authors:  Rachel Krasnow McEntee; David Coyle; Markus Meyer
Journal:  Circ Heart Fail       Date:  2011-05       Impact factor: 8.790

6.  A case of transient left ventricular ballooning with pheochromocytoma, supporting pathogenetic role of catecholamines in stress-induced cardiomyopathy or takotsubo cardiomyopathy.

Authors:  Masataka Takizawa; Naoshi Kobayakawa; Hiroki Uozumi; Shigeto Yonemura; Takahide Kodama; Kazuyuki Fukusima; Hiroaki Takeuchi; Yukihiro Kaneko; Tomoyuki Kaneko; Kiichirou Fujita; Yukio Honma; Teruhiko Aoyagi
Journal:  Int J Cardiol       Date:  2006-10-18       Impact factor: 4.164

Review 7.  [Pheochromocytoma and sudden death: a case of hyperacute myocardial ischemia].

Authors:  E Cardesi; G Cera; A Cassia
Journal:  Pathologica       Date:  1994-12

8.  Pheochromocytoma crisis presenting with shock and tako-tsubo-like cardiomyopathy.

Authors:  Elisabeth Lassnig; Thomas Weber; Johann Auer; Roland Nömeyer; Bernd Eber
Journal:  Int J Cardiol       Date:  2008-06-24       Impact factor: 4.164

9.  Comparison of diagnostic accuracy of urinary free metanephrines, vanillyl mandelic Acid, and catecholamines and plasma catecholamines for diagnosis of pheochromocytoma.

Authors:  James G Boyle; D Fraser Davidson; Colin G Perry; John M C Connell
Journal:  J Clin Endocrinol Metab       Date:  2007-07-17       Impact factor: 5.958

10.  Pheochromocytoma-induced cardiomyopathy is modulated by the synergistic effects of cell-secreted factors.

Authors:  Hector R Mobine; Aaron B Baker; Libin Wang; Hiroko Wakimoto; Kurt C Jacobsen; Christine E Seidman; J G Seidman; Elazer R Edelman
Journal:  Circ Heart Fail       Date:  2009-02-10       Impact factor: 8.790

  10 in total

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