Literature DB >> 31761983

Human Umbilical Cord Blood Serum/Plasma: Cytokine Profile and Prospective Application in Regenerative Medicine.

Yu A Romanov1,2, V V Vtorushina3, T N Dugina4, A Yu Romanov3, N V Petrova4.   

Abstract

The concentrations of cytokines and growth factors in human umbilical cord blood serum and plasma samples were measured by multiplex analysis. It was found that in comparison with peripheral blood serum of adult donors, umbilical cord blood serum and plasma contain significantly higher concentrations of the most studied molecules including IL-4, 5, 6, 7, 10 and 15, MCP-1, SCF, and SDF, as well as growth factors directly involved in the processes of regeneration (G-CSF, HGF, PDGF-BB, and VEGF). Thus, umbilical cord blood plasma and especially serum are a rich source of cytokines and growth factors with anti-inflammatory, anti-apoptotic, and angiogenic effects and can be used in various fields of regenerative medicine.

Entities:  

Keywords:  cord blood serum; cytokines; growth factors; regenerative medicine; |cord blood plasma

Mesh：

Substances：

Year:  2019        PMID： 31761983     DOI： 10.1007/s10517-019-04670-2

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  5 in total

1.  Cord blood serum harvesting by hydroxyethyl starch: a fetal bovine serum alternative in expansion of umbilical cord-derived mesenchymal stem cells.

Authors:  Maryam Samareh Salavati Pour; Reza Vahidi; Mahla Lashkari; Ali Derakhshani; Zahra Ameri; Alireza Farsinejad
Journal:  Cytotechnology       Date:  2020-06-29       Impact factor: 2.058

Review 2.  Regenerative Therapy Using Umbilical Cord Serum.

Authors:  Nagarajan Maharajan; Gwang-Won Cho; Ji Hyun Choi; Chul Ho Jang
Journal:  In Vivo       Date:  2021 Mar-Apr       Impact factor: 2.155

3.  A critical appraisal of humanized alternatives to fetal bovine serum for clinical applications of umbilical cord derived mesenchymal stromal cells.

Authors:  Suneel Rallapalli; Soma Guhathakurta; Dillip Kumar Bishi; Rajasekaran Subbarayan; Santosh Mathapati; Purna Sai Korrapati
Journal:  Biotechnol Lett       Date:  2021-09-09       Impact factor: 2.461

4.  Tubulin-binding peptide RR-171 derived from human umbilical cord serum displays antitumor activity against hepatocellular carcinoma via inducing apoptosis and activating the NF-kappa B pathway.

Authors:  Donglie Zhu; Cheng Fang; Zelong Yang; Yanjie Ren; Fengrui Yang; Shi Zheng; Mingzuo Jiang; Xiangxia Miao; Duoduo Liu; Biliang Chen; Xuebiao Yao; Yong Chen
Journal:  Cell Prolif       Date:  2022-05-03       Impact factor: 8.755

5.  Organotypic Culture of Testicular Tissue from Infant Boys with Cryptorchidism.

Authors:  Danyang Wang; Simone Hildorf; Elissavet Ntemou; Linn Salto Mamsen; Lihua Dong; Susanne Elisabeth Pors; Jens Fedder; Erik Clasen-Linde; Dina Cortes; Jørgen Thorup; Claus Yding Andersen
Journal:  Int J Mol Sci       Date:  2022-07-19       Impact factor: 6.208
  5 in total

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