| Literature DB >> 31761922 |
Dongsik Park1, Sooseok Im, Gurusamy Saravanakumar, Yeong Mi Lee, Jinhwan Kim, Kunho Kim, Junseok Lee, Jihoon Kim, Won Jong Kim.
Abstract
We have reported rational design of a polymeric NO delivery micelle as a cytosol-selective NO bomb. Protected NO-donors are released from the micelle under endolysosomal conditions, and then deprotected by cytosolic glutathione. Cytosol-selective NO delivery facilitates significant tumor regression without the aid of other therapeutic modalities even in intravenous administrations.Entities:
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Year: 2019 PMID： 31761922 DOI： 10.1039/c9cc08028g
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222