Dongsheng Di1, Linlin Zhang1, Xiaoxiao Wu1, Ruixue Leng2. 1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui 230032, China. 2. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui 230032, China. Electronic address: lengruixue@ahmu.edu.cn.
Abstract
OBJECTIVES: Air pollution ranks high among risk factors for the global burden of disease. The associations of air pollution and rheumatoid arthritis (RA) are controversial. This systematic review and meta-analyses has analyzed the association between outdoor air pollution and the development of RA. METHODS: PubMed, Embase and Web of science (last search, May 21, 2019) were searched. A meta-analysis was performed with a random-effects model, and summarized syntheses effects were expressed as relative risks (RRs). RESULTS: Eight studies were identified from among 1296 articles. The pooled RR for the association between ozone (O3) exposure and RA was 1.16 (95% CI: 1.15, 1.18). The pooled RR for the association of RA risk with proximity to traffic road was 1.34 (95% CI: 1.11, 1.62) for residence ≤ 50 m from a traffic road compared with residence more far away. In contrast, there was an inverse effect between PM2.5 exposure and incident RA, and similar result of PM10 was found by subgroup analysis in seropositive RA. In addition, there was no clear evidence between exposing to PM10, CO, NO2 and NO2 (tenth year prior) and RA risk. CONCLUSION: Existing evidence indicated significant associations between some markers (ozone, proximity to traffic road and PM2.5) of air pollution and RA. For generalizability of evidence, that research should be extended to developing countries where air pollution (including indoor) is high may provide more complete insight into risk factors for RA.
OBJECTIVES: Air pollution ranks high among risk factors for the global burden of disease. The associations of air pollution and rheumatoid arthritis (RA) are controversial. This systematic review and meta-analyses has analyzed the association between outdoor air pollution and the development of RA. METHODS: PubMed, Embase and Web of science (last search, May 21, 2019) were searched. A meta-analysis was performed with a random-effects model, and summarized syntheses effects were expressed as relative risks (RRs). RESULTS: Eight studies were identified from among 1296 articles. The pooled RR for the association between ozone (O3) exposure and RA was 1.16 (95% CI: 1.15, 1.18). The pooled RR for the association of RA risk with proximity to traffic road was 1.34 (95% CI: 1.11, 1.62) for residence ≤ 50 m from a traffic road compared with residence more far away. In contrast, there was an inverse effect between PM2.5 exposure and incident RA, and similar result of PM10 was found by subgroup analysis in seropositive RA. In addition, there was no clear evidence between exposing to PM10, CO, NO2 and NO2 (tenth year prior) and RA risk. CONCLUSION: Existing evidence indicated significant associations between some markers (ozone, proximity to traffic road and PM2.5) of air pollution and RA. For generalizability of evidence, that research should be extended to developing countries where air pollution (including indoor) is high may provide more complete insight into risk factors for RA.
Authors: Giovanni Adami; Marco Pontalti; Giorgio Cattani; Maurizio Rossini; Ombretta Viapiana; Giovanni Orsolini; Camilla Benini; Eugenia Bertoldo; Elena Fracassi; Davide Gatti; Angelo Fassio Journal: RMD Open Date: 2022-02
Authors: Md M Hossain; Jesse Wilkerson; John A McGrath; Payam N Farhadi; Cole Brokamp; Md T F Khan; Bob Goldberg; Hermine I Brunner; Maurizio Macaluso; Frederick W Miller; Lisa G Rider Journal: Front Med (Lausanne) Date: 2022-03-16