Literature DB >> 3176062

Biologically motivated two-stage model for cancer risk assessment.

S H Moolgavkar1.   

Abstract

A model for carcinogenesis is presented that incorporates two features: (1) transition of target stem cells into cancer cells via an intermediate stage in two irreversible steps, and (2) growth and differentiation of normal target and intermediate cells. Implications of the model for initiation-promotion and environmental carcinogenesis are considered.

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Year:  1988        PMID： 3176062     DOI： 10.1016/0378-4274(88)90025-2

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  7 in total

1.  Human fetal/tumor metakaryotic stem cells: pangenomic homologous pairing and telomeric end-joining of chromatids.

Authors:  Amanda N Gruhl; Elena V Gostjeva; William G Thilly; Janna N Fomina; Firouz Darroudi
Journal:  Cancer Genet Cytogenet       Date:  2010-12

2.  Mechanistic Models Fit to ED001 Data on >40,000 Trout Exposed to Dibenzo[A,L]pyrene Indicate Mutations Do Not Drive Increased Tumor Risk.

Authors:  Kenneth T Bogen
Journal:  Dose Response       Date:  2014-01-10       Impact factor: 2.658

3.  Cutting Edge PBPK Models and Analyses: Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology Paradigms.

Authors:  Jane C Caldwell; Marina V Evans; Kannan Krishnan
Journal:  J Toxicol       Date:  2012-07-30

4.  Stem cell niche dynamics: from homeostasis to carcinogenesis.

Authors:  Kevin S Tieu; Ryan S Tieu; Julian A Martinez-Agosto; Mary E Sehl
Journal:  Stem Cells Int       Date:  2012-02-09       Impact factor: 5.443

5.  Evaluating the number of stages in development of squamous cell and adenocarcinomas across cancer sites using human population-based cancer modeling.

Authors:  Julia Kravchenko; Igor Akushevich; Amy P Abernethy; H Kim Lyerly
Journal:  PLoS One       Date:  2012-05-22       Impact factor: 3.240

Review 6.  Mutator/Hypermutable fetal/juvenile metakaryotic stem cells and human colorectal carcinogenesis.

Authors:  Lohith G Kini; Pablo Herrero-Jimenez; Tushar Kamath; Jayodita Sanghvi; Efren Gutierrez; David Hensle; John Kogel; Rebecca Kusko; Karl Rexer; Ray Kurzweil; Paulo Refinetti; Stephan Morgenthaler; Vera V Koledova; Elena V Gostjeva; William G Thilly
Journal:  Front Oncol       Date:  2013-10-29       Impact factor: 6.244

Review 7.  Age-specific carcinogenesis: environmental exposure and susceptibility.

Authors:  R D Thomas
Journal:  Environ Health Perspect       Date:  1995-09       Impact factor: 9.031
  7 in total

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