Literature DB >> 31759820

Adult Acute Lymphoblastic Leukemia: Treatment and Management Updates.

Stephanie Gregory1.   

Abstract

OBJECTIVE: To present an overview of novel therapies for the treatment of adult acute lymphoblastic leukemia and to discuss nursing implications for these new therapies. DATA SOURCES: Published manuscripts, Web sites, and pharmaceutical package inserts.
CONCLUSION: Several promising therapies have emerged in the treatment of relapsed/refractory and minimal residual disease acute lymphoblastic leukemia. IMPLICATIONS FOR NURSING PRACTICE: With the changing paradigm for hematologic malignancies, nurses must remain current in their knowledge regarding novel therapies, including their administration, toxicity profile, and management of adverse events. This article addresses the clinical benefits of novel agents and nursing implications for those agents.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  CAR-T cell therapy; acute lymphoblastic leukemia; bispecific antibodies; blinatumumab; cytokine release syndrome; inotuzumab ozogamicin; novel therapies

Mesh:

Substances:

Year:  2019        PMID: 31759820     DOI: 10.1016/j.soncn.2019.150951

Source DB:  PubMed          Journal:  Semin Oncol Nurs        ISSN: 0749-2081            Impact factor:   2.315


  4 in total

1.  Polycationic peptide R7-G-Aβ25-35 selectively induces cell death in leukemia Jurkat T cells through speedy mitochondrial depolarization, and CASPASE-3 -independent mechanism.

Authors:  Miguel Mendivil-Perez; Marlene Jimenez-Del-Rio; Carlos Velez-Pardo
Journal:  Biochem Biophys Rep       Date:  2022-06-18

2.  In vitro and in vivo effects of AVA4746, a novel competitive antagonist of the ligand binding of VLA-4, in B-cell acute lymphoblastic leukemia.

Authors:  Yongsheng Ruan; Hye Na Kim; Heather A Ogana; Eun Ji Gang; Shuangyue Li; Hsiao-Chuan Liu; Deepa Bhojwani; Alan S Wayne; Mo Yang; Yong-Mi Kim
Journal:  Exp Ther Med       Date:  2021-11-15       Impact factor: 2.447

Review 3.  Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia.

Authors:  Yang Song; Qiuyun Fang; Yingchang Mi
Journal:  Front Oncol       Date:  2022-08-04       Impact factor: 5.738

4.  PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability.

Authors:  Ling Jin; Laigen Tong
Journal:  Immun Inflamm Dis       Date:  2021-05-06
  4 in total

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