Cristina Oana Mărginean1, Lorena Elena Meliţ2, Adina Huțanu3, Dana Valentina Ghiga4, Maria Oana Săsăran5. 1. Department of Pediatrics, University of Medicine, Pharmacy, Sciences and Technology Târgu Mureș, Gheorghe Marinescu street no 38, Târgu Mureș 540136, Romania. 2. Department of Pediatrics, University of Medicine, Pharmacy, Sciences and Technology Târgu Mureș, Gheorghe Marinescu street no 38, Târgu Mureș 540136, Romania. Electronic address: lory_chimista89@yahoo.com. 3. Research Laboratory, Center for Advanced Medical and Pharmaceutical Research, University of Medicine, Pharmacy, Sciences and Technology Târgu Mureș, Gheorghe Marinescu street no 38, Târgu Mureș 540136, Romania. 4. Department of Medical Informatics and Biostatistics, University of Medicine, Pharmacy, Sciences and Technology Târgu Mureș, Gheorghe Marinescu street no 38, Târgu Mureș 540136, Romania. 5. Department of Pediatric Cardiology, University of Medicine, Pharmacy, Sciences and Technology, Romania, Târgu Mureș, Gheorghe Marinescu street no 38, Târgu Mureș 540136, Romania.
Abstract
INTRODUCTION: Obesity is associated with a chronic inflammation due to the deficiency in immune activity related to adipose tissue. A wide-spectrum of pro-inflammatory cytokines secreted by adipocytes play an important role in the assessment of obesity-associated inflammatory status. The aim of this study was to assess the relationship between IL and 1β, IL-6, TNF α, leptin, and inflammatory status in children with overweight/obesity. MATERIAL AND METHODS: We performed a cross-sectional study on 193 children, admitted to a Pediatric Tertiary Hospital in Romania. The children were divided according to BMI into: the study group-91 children with overweight/obesity, and the control group-102 children with normal BMI. Demographic, anthropometric, and laboratory parameters including the serum levels of several adipokines (leptin, IL-1β, IL-6, and TNF α) were assessed in both groups. RESULTS: Our findings revealed significantly higher values of leukocytes, lymphocytes, platelets, AST, and ALT, as well as for the lipid metabolism parameters including cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, and CRP, in children with overweight/obesity. We found significantly higher levels of adipokines in the serum of children with overweight and obesity assessed for leptin, IL6, and TNF α (p = 0.0145/p < 0.0001/p = 0.004/), except for IL-1β serum levels. CONCLUSIONS: Childhood overweight and/or obesity is associated with a systemic inflammatory status demonstrated by increased levels of CBC parameters. Pro-inflammatory adipokines are also an essential factor in obesity-related inflammatory status according to our findings that underlined the importance of increased serum levels of IL-6, TNF α, and leptin in pediatric patients with overweight/obesity. Clinically, CBC parameters along with adipokines might represent useful diagnostic tools for low-grade systemic inflammation in children with overweight or obesity.
INTRODUCTION:Obesity is associated with a chronic inflammation due to the deficiency in immune activity related to adipose tissue. A wide-spectrum of pro-inflammatory cytokines secreted by adipocytes play an important role in the assessment of obesity-associated inflammatory status. The aim of this study was to assess the relationship between IL and 1β, IL-6, TNF α, leptin, and inflammatory status in children with overweight/obesity. MATERIAL AND METHODS: We performed a cross-sectional study on 193 children, admitted to a Pediatric Tertiary Hospital in Romania. The children were divided according to BMI into: the study group-91 children with overweight/obesity, and the control group-102 children with normal BMI. Demographic, anthropometric, and laboratory parameters including the serum levels of several adipokines (leptin, IL-1β, IL-6, and TNF α) were assessed in both groups. RESULTS: Our findings revealed significantly higher values of leukocytes, lymphocytes, platelets, AST, and ALT, as well as for the lipid metabolism parameters including cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, and CRP, in children with overweight/obesity. We found significantly higher levels of adipokines in the serum of children with overweight and obesity assessed for leptin, IL6, and TNF α (p = 0.0145/p < 0.0001/p = 0.004/), except for IL-1β serum levels. CONCLUSIONS: Childhood overweight and/or obesity is associated with a systemic inflammatory status demonstrated by increased levels of CBC parameters. Pro-inflammatory adipokines are also an essential factor in obesity-related inflammatory status according to our findings that underlined the importance of increased serum levels of IL-6, TNF α, and leptin in pediatric patients with overweight/obesity. Clinically, CBC parameters along with adipokines might represent useful diagnostic tools for low-grade systemic inflammation in children with overweight or obesity.
Authors: Álvaro González-Domínguez; Francisco M Visiedo-García; Jesús Domínguez-Riscart; Raúl González-Domínguez; Rosa M Mateos; Alfonso María Lechuga-Sancho Journal: Int J Mol Sci Date: 2020-08-01 Impact factor: 5.923