| Literature DB >> 31759225 |
Sherri A McFarland1, Arkady Mandel2, Roger Dumoulin-White2, Gilles Gasser3.
Abstract
Photodynamic therapy (PDT) is an approved medical technique to treat certain forms of cancer. It has been used to complement traditional anticancer modalities such as surgery, chemotherapy or radiotherapy, and in certain cases, to replace these treatments. One critical parameter of PDT is the photosensitizer (PS); historically, a purely organic macrocyclic tetrapyrrole-based structure. This short review surveys two recent clinical examples of metal complexes, namely TOOKAD®-Soluble and TLD-1433, which have ideal photophysical properties to act as PDT PSs. We highlight the important role played by the metal ions in the PS for PDT activity.Entities:
Keywords: Bioinorganic chemistry; Medicinal inorganic chemistry; Metals in medicine; Photodynamic therapy; Photosensitizer
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Year: 2019 PMID： 31759225 PMCID： PMC7237330 DOI： 10.1016/j.cbpa.2019.10.004
Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822