Literature DB >> 31758445

ToxoDB: Functional Genomics Resource for Toxoplasma and Related Organisms.

Omar S Harb1, David S Roos2.   

Abstract

ToxoDB is a free online resource that provides access to genomic and functional genomic data. All data is made available through an intuitive queryable interface that enables scientists to build in silico experiments and develop testable hypothesis. The resource contains 32 fully sequenced and annotated genomes, with genomic sequence from multiple strains available for variant detection and copy number variation analysis. In addition to genomic sequence data, ToxoDB contains numerous functional genomic datasets including microarray, RNAseq, proteomics, ChIP-seq, and phenotypic data. In addition, results from a number of whole-genome analyses are incorporated including mapping to orthology clusters which allows users to leverage phylogenetic relationships in their analyses. Integration of primary data is made possible through a private galaxy interface and custom export tools that allow users to interrogate their own results in the context of all other data in the database.

Keywords:  Apicomplexa; Bioinformatics; Database; EuPathDB; Genomics; ToxoDB

Year:  2020        PMID: 31758445     DOI: 10.1007/978-1-4939-9857-9_2

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN: 1064-3745


  8 in total

1.  Phosphoglucomutase 1 contributes to optimal cyst development in Toxoplasma gondii.

Authors:  Emily V Quach; Binh Cao; Edres Babacarkhial; Daniel Ho; Janak Sharma; Pascale S Guiton
Journal:  BMC Res Notes       Date:  2022-05-21

Review 2.  Complexome Profiling-Exploring Mitochondrial Protein Complexes in Health and Disease.

Authors:  Alfredo Cabrera-Orefice; Alisa Potter; Felix Evers; Johannes F Hevler; Sergio Guerrero-Castillo
Journal:  Front Cell Dev Biol       Date:  2022-01-12

3.  Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in Toxoplasma.

Authors:  Sarah Pamukcu; Aude Cerutti; Yann Bordat; Sonia Hem; Valérie Rofidal; Sébastien Besteiro
Journal:  PLoS Pathog       Date:  2021-11-18       Impact factor: 6.823

4.  Single Cell Transcriptomes of In Vitro Bradyzoite Infected Cells Reveals Toxoplasma gondii Stage Dependent Host Cell Alterations.

Authors:  Tatsuki Sugi; Tadakimi Tomita; Taishi Kidaka; Naoko Kawai; Kyoko Hayashida; Louis M Weiss; Junya Yamagishi
Journal:  Front Cell Infect Microbiol       Date:  2022-03-14       Impact factor: 5.293

5.  Dense Granule Protein GRA64 Interacts with Host Cell ESCRT Proteins during Toxoplasma gondii Infection.

Authors:  Joshua Mayoral; Rebekah B Guevara; Yolanda Rivera-Cuevas; Vincent Tu; Tadakimi Tomita; Julia D Romano; Leslie Gunther-Cummins; Simone Sidoli; Isabelle Coppens; Vernon B Carruthers; Louis M Weiss
Journal:  mBio       Date:  2022-06-22       Impact factor: 7.786

6.  DGPD: a knowledge database of dense granule proteins of the Apicomplexa.

Authors:  Hang Hu; Zhenxiao Lu; Haisong Feng; Guojun Chen; Yongmei Wang; Congshan Yang; Zhenyu Yue
Journal:  Database (Oxford)       Date:  2022-09-27       Impact factor: 4.462

7.  OGEE v3: Online GEne Essentiality database with increased coverage of organisms and human cell lines.

Authors:  Sanathoi Gurumayum; Puzi Jiang; Xiaowen Hao; Tulio L Campos; Neil D Young; Pasi K Korhonen; Robin B Gasser; Peer Bork; Xing-Ming Zhao; Li-Jie He; Wei-Hua Chen
Journal:  Nucleic Acids Res       Date:  2021-01-08       Impact factor: 16.971

8.  A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii.

Authors:  Zhu-Hong Li; Thayer P King; Lawrence Ayong; Beejan Asady; Xinjiang Cai; Taufiq Rahman; Stephen A Vella; Isabelle Coppens; Sandip Patel; Silvia N J Moreno
Journal:  Nat Commun       Date:  2021-10-04       Impact factor: 14.919

  8 in total

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