| Literature DB >> 3175763 |
M G Wathelet1, J Szpirer, C B Nols, I M Clauss, L De Wit, M Q Islam, G Levan, M A Horisberger, J Content, C Szpirer.
Abstract
When cells are treated with interferon several new proteins are induced. We have isolated by differential screening two cDNA clones corresponding to human genes inducible by IFN-alpha, termed IFI-4 and IFI-54K. The accumulation of the corresponding mRNA was followed as a function of either IFN dose or of time. The IFI-4 and IFI-54K genes, as well as two previously isolated IFN-inducible genes, namely the IFI-56K and low-molecular-weight 2-5A synthetase, were localized on the human chromosomes. Using cloned probes on Southern blots of DNA from a panel of rodent-human somatic cell hybrids, we have assigned the IFI-4 gene to chromosome 1 and the gene coding for the low-molecular-weight 2-5A synthetase to chromosome 12. We also showed that the IFI-54K and IFI-56K genes, unlike most of the IFN-inducible genes, are syntenic. They are both located on chromosome 10. In addition, evidence is given for the presence of a pseudogene homologous to IFI-56K on chromosome 13.Entities:
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Year: 1988 PMID： 3175763 DOI： 10.1007/bf01534709
Source DB: PubMed Journal: Somat Cell Mol Genet ISSN： 0740-7750