Dieyi Chen1, Fatemeh Mayvaneh2, Mohammad Baaghideh2, Alireza Entezari2, Hung Chak Ho3, Qianqian Xiang4, Anqi Jiao5, Faxue Zhang5, Kejia Hu6, Gongbo Chen1, Qi Zhao7, Shengzhi Sun8, Yunquan Zhang9. 1. Department of Global Health, School of Health Sciences, Wuhan University, Wuhan 430071, China. 2. Faculty of Geography and Environmental Sciences, Hakim Sabzevari University, Sabzevar 9617916487, Khorasan Razavi, Iran. 3. Department of Urban Planning and Design, The University of Hong Kong, Hong Kong, China. 4. Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China. 5. Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan 430071, China. 6. Department of Precision Health and Data Science, School of Public Health, Zhejiang University, Hangzhou 310003, China. 7. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia. 8. Department of Epidemiology, Brown University School of Public Health, Providence, RI 02912, USA. 9. Department of Epidemiology and Biostatistics, School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China; Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, China. Electronic address: YunquanZhang@wust.edu.cn.
Abstract
BACKGROUND: Evidence for associations between fine particulate matter (PM2.5) and cardiovascular diseases (CVDs) in Iran is scarce. Given large within-day variations of PM2.5 concentration, using the daily mean of PM2.5 (PM2.5mean) as exposure metric might bias the health-related assessment. This study applied a novel indicator, daily excessive concentration hours (DECH), to evaluate the effect of ambient PM2.5 on CVD mortality and years of life lost (YLL) in Tehran, the capital city of Iran. METHODS: Hourly concentration data for PM2.5, daily information for meteorology and records of registered cardiovascular deaths from 2012 to 2016 were obtained from Tehran, Iran. Daily excessive concentration hours of PM2.5 (PM2.5DECH) was defined as daily total concentration-hours exceeding 35 μg/m3. Using a time-series design, we applied generalized linear models to assess the attributable effects of PM2.5DECH and PM2.5mean on CVD mortality and YLL. RESULTS: For an interquartile range (IQR) rise in PM2.5DECH, total CVD mortality at lag 0-10 days and YLL at lag 0-8 days increased 2.26% (95% confidence interval (CI): 0.85-3.69%) and 23.24 (6.07-40.42) person years, respectively. Corresponding increases were 3.45% (1.44-5.49%) and 35.21 (10.85-59.58) person years for an IQR rise in PM2.5mean. Significant associations between PM2.5 pollution (i.e., PM2.5mean and PM2.5DECH) and cause-specific cardiovascular health (i.e., mortality and YLL) were only identified in stroke. Subgroup analyses showed that male and people aged 0-64 years suffered more from PM2.5 pollution. Furthermore, we attributed a greater CVD burden to PM2.5DECH (1.67% for mortality and 2.67% for YLL) than PM2.5mean (0.63% for mortality and 0.70% for YLL) during the study period. CONCLUSIONS: This study strengthened the evidence for the aggravated CVD mortality burden associated with short-term exposure to PM2.5. Our findings also suggested that PM2.5DECH might be a potential alternative indicator of exposure assessment in PM2.5-related health investigations.
BACKGROUND: Evidence for associations between fine particulate matter (PM2.5) and cardiovascular diseases (CVDs) in Iran is scarce. Given large within-day variations of PM2.5 concentration, using the daily mean of PM2.5 (PM2.5mean) as exposure metric might bias the health-related assessment. This study applied a novel indicator, daily excessive concentration hours (DECH), to evaluate the effect of ambient PM2.5 on CVDmortality and years of life lost (YLL) in Tehran, the capital city of Iran. METHODS: Hourly concentration data for PM2.5, daily information for meteorology and records of registered cardiovascular deaths from 2012 to 2016 were obtained from Tehran, Iran. Daily excessive concentration hours of PM2.5 (PM2.5DECH) was defined as daily total concentration-hours exceeding 35 μg/m3. Using a time-series design, we applied generalized linear models to assess the attributable effects of PM2.5DECH and PM2.5mean on CVDmortality and YLL. RESULTS: For an interquartile range (IQR) rise in PM2.5DECH, total CVDmortality at lag 0-10 days and YLL at lag 0-8 days increased 2.26% (95% confidence interval (CI): 0.85-3.69%) and 23.24 (6.07-40.42) person years, respectively. Corresponding increases were 3.45% (1.44-5.49%) and 35.21 (10.85-59.58) person years for an IQR rise in PM2.5mean. Significant associations between PM2.5 pollution (i.e., PM2.5mean and PM2.5DECH) and cause-specific cardiovascular health (i.e., mortality and YLL) were only identified in stroke. Subgroup analyses showed that male and people aged 0-64 years suffered more from PM2.5 pollution. Furthermore, we attributed a greater CVD burden to PM2.5DECH (1.67% for mortality and 2.67% for YLL) than PM2.5mean (0.63% for mortality and 0.70% for YLL) during the study period. CONCLUSIONS: This study strengthened the evidence for the aggravated CVDmortality burden associated with short-term exposure to PM2.5. Our findings also suggested that PM2.5DECH might be a potential alternative indicator of exposure assessment in PM2.5-related health investigations.
Authors: Yang Ni; Wang Song; Yu Bai; Tao Liu; Guoxing Li; Ying Bian; Qiang Zeng Journal: Int J Environ Res Public Health Date: 2021-10-31 Impact factor: 3.390