Literature DB >> 31757314

Precision Medicine in Pediatric Oncology.

Kieuhoa T Vo1, D Williams Parsons2, Nita L Seibel3.   

Abstract

Improvements in outcome have been seen in children and adolescents with cancer. Nevertheless, challenges remain in trying to improve the outcomes for all children diagnosed with cancer, particularly in patients with metastatic disease or with cancers that are resistant or recur after standard treatment. Precision medicine trials using individualized tumor molecular profiling for selection of targeted therapies are ongoing in adult malignancies. Similar approaches are being applied to children and adolescents with cancer. This article describes how precision medicine is being applied to pediatric oncology and the unique challenges being faced with these efforts. Published by Elsevier Inc.

Entities:  

Keywords:  Genomic profiling; Next-generation sequencing; Pediatric cancer; Precision medicine; Targeted therapy

Year:  2019        PMID： 31757314     DOI： 10.1016/j.soc.2019.08.005

Source DB:  PubMed          Journal:  Surg Oncol Clin N Am        ISSN： 1055-3207            Impact factor:   3.495


  6 in total

1.  Parental Attitudes toward Artificial Intelligence-Driven Precision Medicine Technologies in Pediatric Healthcare.

Authors:  Bryan A Sisk; Alison L Antes; Sara Burrous; James M DuBois
Journal:  Children (Basel)       Date:  2020-09-20

Review 2.  From Patient Engagement to Precision Oncology: Leveraging Informatics to Advance Cancer Care.

Authors:  Ashley C Griffin; Umit Topaloglu; Sean Davis; Arlene E Chung
Journal:  Yearb Med Inform       Date:  2020-08-21

Review 3.  Precision Medicine in Osteosarcoma: MATCH Trial and Beyond.

Authors:  Elisa Tirtei; Anna Campello; Sebastian D Asaftei; Katia Mareschi; Matteo Cereda; Franca Fagioli
Journal:  Cells       Date:  2021-01-31       Impact factor: 6.600

Review 4.  Relapsed Medulloblastoma in Pre-Irradiated Patients: Current Practice for Diagnostics and Treatment.

Authors:  Rebecca M Hill; Sabine L A Plasschaert; Beate Timmermann; Christelle Dufour; Kristian Aquilina; Shivaram Avula; Laura Donovan; Maarten Lequin; Torsten Pietsch; Ulrich Thomale; Stephan Tippelt; Pieter Wesseling; Stefan Rutkowski; Steven C Clifford; Stefan M Pfister; Simon Bailey; Gudrun Fleischhack
Journal:  Cancers (Basel)       Date:  2021-12-28       Impact factor: 6.575

5.  Genetic polymorphisms of genes involved in oxidative stress and inflammatory management in oncopediatric patients with chemo-induced oral mucositis.

Authors:  Marina Castro Coêlho; José Maria Chagas Viana Filho; Beatriz Fernandes de Souza; Ana Maria Gondim Valença; Darlene Camati Persuhn; Naila Francis Paulo de Oliveira
Journal:  J Appl Oral Sci       Date:  2022-03-23       Impact factor: 2.698

Review 6.  Precision Medicine Highlights Dysregulation of the CDK4/6 Cell Cycle Regulatory Pathway in Pediatric, Adolescents and Young Adult Sarcomas.

Authors:  Farinaz Barghi; Harlan E Shannon; M Reza Saadatzadeh; Barbara J Bailey; Niknam Riyahi; Khadijeh Bijangi-Vishehsaraei; Marissa Just; Michael J Ferguson; Pankita H Pandya; Karen E Pollok
Journal:  Cancers (Basel)       Date:  2022-07-25       Impact factor: 6.575
  6 in total

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