Literature DB >> 31757309

Oral Cancer: Genetics and the Role of Precision Medicine.

Chia-Cheng Li1, Zhen Shen2, Roxanne Bavarian3, Fan Yang2, Aditi Bhattacharya4.   

Abstract

Oral squamous cell carcinoma (OSCC) is one of the leading cancers in the world. OSCC patients are managed with surgery and/or chemoradiation. Prognoses and survival rates are dismal, however, and have not improved for more than 20 years. Recently, the concept of precision medicine was introduced, and the introduction of targeted therapeutics demonstrated promising outcomes. This article reviews the current understanding of initiation, progression, and metastasis of OSCC from both genetic and epigenetic perspectives. In addition, the applications and integration of omics technologies in biomarker discovery and drug development for treating OSCC are reviewed.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Big data; Epigenetics; Malignant transformation; Omics technology; Oral cancer; Oral squamous cell carcinoma; Personalized medicine; Precision medicine

Year:  2020        PMID： 31757309     DOI： 10.1016/j.soc.2019.08.010

Source DB:  PubMed          Journal:  Surg Oncol Clin N Am        ISSN： 1055-3207            Impact factor:   3.495


  9 in total

1.  Pro-Apoptotic Antitumoral Effect of Novel Acridine-Core Naphthoquinone Compounds against Oral Squamous Cell Carcinoma.

Authors:  Bruna Costa Zorzanelli; Gabriel Ouverney; Fernanda P Pauli; Anna Carolina Carvalho da Fonseca; Elan Cardozo Paes de Almeida; Danielle Gonçalves de Carvalho; Patricia Abrão Possik; Vitor Won-Held Rabelo; Paula Alvarez Abreu; Bruno Pontes; Vitor Francisco Ferreira; Luana da Silva Magalhães Forezi; Fernando de Carvalho da Silva; Bruno Kaufmann Robbs
Journal:  Molecules       Date:  2022-08-12       Impact factor: 4.927

2.  Assessing Gene Expression Related to Cisplatin Resistance in Human Oral Squamous Cell Carcinoma Cell Lines.

Authors:  Hyeong Sim Choi; Young-Kyun Kim; Pil-Young Yun
Journal:  Pharmaceuticals (Basel)       Date:  2022-06-03

3.  Prognostic significance of a 4-lncRNA glycolysis-related signature in oral squamous cell carcinoma.

Authors:  Liangyin Wu; Jun Liu; Wenli Li
Journal:  J Dent Sci       Date:  2021-11-27       Impact factor: 3.719

4.  Tanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis.

Authors:  Ming Li; Feng Gao; Qing Zhao; Huilan Zuo; Wenbin Liu; Wei Li
Journal:  Cell Death Dis       Date:  2020-05-18       Impact factor: 8.469

5.  Targeting Aurora B kinase with Tanshinone IIA suppresses tumor growth and overcomes radioresistance.

Authors:  Ming Li; Haidan Liu; Qin Zhao; Shuangze Han; Li Zhou; Wenbin Liu; Wei Li; Feng Gao
Journal:  Cell Death Dis       Date:  2021-02-04       Impact factor: 8.469

6.  Carnosic Acid Suppresses the Development of Oral Squamous Cell Carcinoma via Mitochondrial-Mediated Apoptosis.

Authors:  Fenghe Min; Xin Liu; Yuan Li; Mingyuan Dong; Yidi Qu; Weiwei Liu
Journal:  Front Oncol       Date:  2021-11-26       Impact factor: 6.244

7.  Upregulation of IGF2BP2 Promotes Oral Squamous Cell Carcinoma Progression That Is Related to Cell Proliferation, Metastasis and Tumor-Infiltrating Immune Cells.

Authors:  Lijie Zhou; Hongyu Li; Hongshi Cai; Wenhui Liu; Enjiu Pan; Dongsheng Yu; Shuai He
Journal:  Front Oncol       Date:  2022-03-01       Impact factor: 6.244

8.  PDGF-BB regulates the transformation of fibroblasts into cancer-associated fibroblasts via the lncRNA LURAP1L-AS1/LURAP1L/IKK/IκB/NF-κB signaling pathway.

Authors:  Xiaobin Ren; Lei Li; Jianhua Wu; Ken Lin; Yongwen He; Li Bian
Journal:  Oncol Lett       Date:  2021-05-19       Impact factor: 2.967

9.  Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinoma.

Authors:  Ming Li; Feng Gao; Xinfang Yu; Qing Zhao; Li Zhou; Wenbin Liu; Wei Li
Journal:  J Exp Clin Cancer Res       Date:  2020-05-14
  9 in total

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