Gary M Shaw1, Jonathan A Mayo1, Michael L Eisenberg2, Ralph Catalano3, David K Stevenson1. 1. March of Dimes Prematurity Research Center at Stanford University, Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California. 2. Department of Urology, Stanford University School of Medicine, Stanford, California. 3. School of Public Health, University of California, Berkeley, Berkeley, California.
Abstract
OBJECTIVE: An observed disparity in population-scale data are a larger number of males among preterm births (PTBs). We investigated spontaneous PTB risk among women of various race/ethnic groups in combination with infants' sex. STUDY DESIGN: This observational study was conducted in > 10 million California births (1991-2012) using birth certificates linked with maternal and infant hospital discharge data. RESULTS: Male-to-female ratios among term (37-42 weeks) infants exhibited the narrow ratio range 1.02 to 1.06 across race/ethnic groups. Such ratios among spontaneous PTBs were generally larger for all race/ethnic groups except non-Hispanic blacks. For blacks, ratios tended to be lower and similar to their term birth counterpart, 1.03. Hazard ratios adjusted for maternal age and education for non-Hispanic blacks were 0.99 (95% confidence interval [CI] 0.90-1.09), 1.01 (95% CI 0.95-1.08), 0.98 (95% CI 0.94-1.03), and 1.03 (95% CI 1.01-1.05), respectively, for gestational week groupings of 20 to 23, 24 to 27, 28 to 321, and 32 to 36. Hazard ratios for non-Hispanic whites for the same groupings were 1.08 (95% CI 0.98-1.18), 1.13 (95% CI 1.07-1.19), 1.21 (95% CI 1.17-1.25), and 1.18 (95% CI 1.17-1.19). CONCLUSION: Why male-to-female ratios are similar across gestational ages in blacks but substantially higher in other race/ethnic groups is theoretically considered relative to inflammation, stress, and other influences. Thieme. All rights reserved.
OBJECTIVE: An observed disparity in population-scale data are a larger number of males among preterm births (PTBs). We investigated spontaneous PTB risk among women of various race/ethnic groups in combination with infants' sex. STUDY DESIGN: This observational study was conducted in > 10 million California births (1991-2012) using birth certificates linked with maternal and infant hospital discharge data. RESULTS: Male-to-female ratios among term (37-42 weeks) infants exhibited the narrow ratio range 1.02 to 1.06 across race/ethnic groups. Such ratios among spontaneous PTBs were generally larger for all race/ethnic groups except non-Hispanic blacks. For blacks, ratios tended to be lower and similar to their term birth counterpart, 1.03. Hazard ratios adjusted for maternal age and education for non-Hispanic blacks were 0.99 (95% confidence interval [CI] 0.90-1.09), 1.01 (95% CI 0.95-1.08), 0.98 (95% CI 0.94-1.03), and 1.03 (95% CI 1.01-1.05), respectively, for gestational week groupings of 20 to 23, 24 to 27, 28 to 321, and 32 to 36. Hazard ratios for non-Hispanic whites for the same groupings were 1.08 (95% CI 0.98-1.18), 1.13 (95% CI 1.07-1.19), 1.21 (95% CI 1.17-1.25), and 1.18 (95% CI 1.17-1.19). CONCLUSION: Why male-to-female ratios are similar across gestational ages in blacks but substantially higher in other race/ethnic groups is theoretically considered relative to inflammation, stress, and other influences. Thieme. All rights reserved.
Authors: Ralph Catalano; Deborah Karasek; Tim Bruckner; Joan A Casey; Katherine Saxton; Collette N Ncube; Gary M Shaw; Holly Elser; Alison Gemmill Journal: J Racial Ethn Health Disparities Date: 2021-03-30
Authors: Tim A Bruckner; Samantha Gailey; Abhery Das; Alison Gemmill; Joan A Casey; Ralph Catalano; Gary M Shaw; Jennifer Zeitlin Journal: BMC Pregnancy Childbirth Date: 2021-07-02 Impact factor: 3.007