Literature DB >> 3175653

Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue.

M A Thiede1, G A Rodan.   

Abstract

A survey of rat tissues by RNA analysis, aimed at uncovering the physiological function of the parathyroid hormone-like peptide (PTH-LP) associated with hypercalcemia of malignancy, revealed the presence of a 1.5-kilobase messenger RNA encoding this peptide in lactating mammary glands. PTH-LP messenger RNA is expressed in mammary tissue only during lactation; it appears and disappears rapidly (2 to 4 hours) as a function of the sucking stimulus. The identity of this messenger RNA was confirmed by cloning the rat PTH-LP complementary DNA, which predicts a peptide with strong similarity to the human homolog. Moreover, extracts from lactating mammary tissue stimulated parathyroid hormone-dependent adenylate cyclase. These findings suggest that PTH-LP plays a physiological role in lactation, possibly as a hormone for the mobilization or transfer (or both) of calcium to the milk.

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Year:  1988        PMID： 3175653     DOI： 10.1126/science.3175653

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  56 in total

Review 1.  Parathyroid hormone-related protein.

Authors:  R A Nissenson
Journal:  Rev Endocr Metab Disord       Date:  2000-11       Impact factor: 6.514

2.  Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals.

Authors:  Laura L Hernandez; Karen A Gregerson; Nelson D Horseman
Journal:  Am J Physiol Endocrinol Metab       Date:  2012-02-07       Impact factor: 4.310

3.  Post-partum hypercalcemia in hereditary hyperphosphatasia (juvenile Paget's disease).

Authors:  N Chosich; F Long; R Wong; D J Topliss; J R Stockigt
Journal:  J Endocrinol Invest       Date:  1991 Jul-Aug       Impact factor: 4.256

4.  Prognostic value of immunocytochemical determination of parathyroid hormone-related peptide expression in cells of mammary ductal carcinoma. Analysis of 7 years of the disease course.

Authors:  Paweł Surowiak; Piotr Dziegiel; Rafał Matkowski; Mirosław Sopel; Andrzej Wojnar; Jan Kornafel; Maciej Zabel
Journal:  Virchows Arch       Date:  2003-01-25       Impact factor: 4.064

5.  High levels of a parathyroid hormone-like protein in milk.

Authors:  A A Budayr; B P Halloran; J C King; D Diep; R A Nissenson; G J Strewler
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

6.  Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation.

Authors:  Joshua N VanHouten; Pamela Dann; Andrew F Stewart; Christine J Watson; Michael Pollak; Andrew C Karaplis; John J Wysolmerski
Journal:  J Clin Invest       Date:  2003-11       Impact factor: 14.808

7.  Signaling by N- and C-terminal sequences of parathyroid hormone-related protein in hippocampal neurons.

Authors:  S Fukayama; A H Tashjian; J N Davis; J C Chisholm
Journal:  Proc Natl Acad Sci U S A       Date:  1995-10-24       Impact factor: 11.205

8.  Age-related decrease in the effect of parathyroid hormone-related protein on cytosolic free calcium level and tension in rat aortic smooth muscle.

Authors:  M Ishikawa; Y Ouchi; M Akishita; K Kozaki; K Toba; A Namiki; T Yamaguchi; H Ito; H Orimo
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-05       Impact factor: 3.000

9.  Parathyroid hormone/parathyroid hormone related peptide receptor gene transcripts are expressed from tissue-specific and ubiquitous promoters.

Authors:  K A McCuaig; H S Lee; J C Clarke; H Assar; J Horsford; J H White
Journal:  Nucleic Acids Res       Date:  1995-06-11       Impact factor: 16.971

Review 10.  Mechanisms of bone metastases of breast cancer.

Authors:  Larry J Suva; Robert J Griffin; Issam Makhoul
Journal:  Endocr Relat Cancer       Date:  2009-05-14       Impact factor: 5.678
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