Marian Sarala1, Jouko Miettunen2,3, Jari Koskela1, Antti Mustonen2, Richard J Rose4, Tuula Hurtig1,5,6, Juha Veijola1,3,7, Solja Niemelä8,9. 1. Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland. 2. Center for Life Course Health Research, University of Oulu, Oulu, Finland. 3. Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. 4. Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA. 5. PEDEGO Research Unit, Child Psychiatry, University of Oulu, Oulu, Finland. 6. Clinic of Child Psychiatry, Oulu University Hospital, Oulu, Finland. 7. Department of Psychiatry, Oulu University Hospital, Oulu, Finland. 8. Department of Psychiatry, University of Turku, Turku, Finland. 9. Addiction Psychiatry Unit, Department of Psychiatry, Hospital District of Southwest Finland, Turku, Finland.
Abstract
AIMS: To assess the associations of intoxication frequency and number of drinks needed to become intoxicated in mid-adolescence with onset of psychiatric disorders in early adulthood. DESIGN, SETTING AND PARTICIPANTS: Prospective cohort study in Northern Finland, with people from the Northern Finland Birth Cohort 1986 who self-reported adolescent alcohol use: 6548 subjects (69.4% of the original sample). Data on alcohol use were collected using questionnaires at ages 15-16 years. MEASUREMENTS: Outcomes were any non-organic psychosis, mood disorder, anxiety disorder, any substance use disorder (SUD) and all the studied psychiatric disorders in early adulthood gathered from nation-wide health care, pension and insurance registers. Number of drinks needed to become intoxicated was categorized into three classes: (1) no alcohol use or intoxication, and (2) low and (3) high alcohol tolerance (more than seven/nine drinks for females/males) groups. Similarly, intoxication frequency was divided into three classes: (1) never, (2) one to two times and (3) three or more times during the past 30 days. Information regarding gender, family type, other drug use, psychopathology using Youth Self-Report (YSR) total score and parental psychiatric disorders were used as covariates. FINDINGS: In the multivariable analyses, both low [odds ratio (OR) = 3.0, 95% confidence interval (CI) = 1.3-6.7, P-value = 0.009] and high (OR = 4.4, 95% CI = 1.8-11.1, P-value = 0.001) alcohol tolerance were associated with increased risk of SUD. More frequent intoxication was associated with increased frequency of SUD (OR = 3.9, 95% CI = 2.0-7.3, P-value < 0.001) and mood disorder (OR = 1.6, 95% CI = 1.1-2.3, P-value = 0.008). The latter was attenuated after adjusting with concurrent psychopathology (YSR) and other drug use. CONCLUSIONS: Both higher alcohol tolerance and frequent intoxication in adolescence appear to be associated with increased risk of future substance use disorder.
AIMS: To assess the associations of intoxication frequency and number of drinks needed to become intoxicated in mid-adolescence with onset of psychiatric disorders in early adulthood. DESIGN, SETTING AND PARTICIPANTS: Prospective cohort study in Northern Finland, with people from the Northern Finland Birth Cohort 1986 who self-reported adolescent alcohol use: 6548 subjects (69.4% of the original sample). Data on alcohol use were collected using questionnaires at ages 15-16 years. MEASUREMENTS: Outcomes were any non-organic psychosis, mood disorder, anxiety disorder, any substance use disorder (SUD) and all the studied psychiatric disorders in early adulthood gathered from nation-wide health care, pension and insurance registers. Number of drinks needed to become intoxicated was categorized into three classes: (1) no alcohol use or intoxication, and (2) low and (3) high alcohol tolerance (more than seven/nine drinks for females/males) groups. Similarly, intoxication frequency was divided into three classes: (1) never, (2) one to two times and (3) three or more times during the past 30 days. Information regarding gender, family type, other drug use, psychopathology using Youth Self-Report (YSR) total score and parental psychiatric disorders were used as covariates. FINDINGS: In the multivariable analyses, both low [odds ratio (OR) = 3.0, 95% confidence interval (CI) = 1.3-6.7, P-value = 0.009] and high (OR = 4.4, 95% CI = 1.8-11.1, P-value = 0.001) alcohol tolerance were associated with increased risk of SUD. More frequent intoxication was associated with increased frequency of SUD (OR = 3.9, 95% CI = 2.0-7.3, P-value < 0.001) and mood disorder (OR = 1.6, 95% CI = 1.1-2.3, P-value = 0.008). The latter was attenuated after adjusting with concurrent psychopathology (YSR) and other drug use. CONCLUSIONS: Both higher alcohol tolerance and frequent intoxication in adolescence appear to be associated with increased risk of future substance use disorder.
Authors: Alvaro Vergés; Matthew R Lee; Christopher S Martin; Timothy J Trull; Matthew P Martens; Phillip K Wood; Kenneth J Sher Journal: Psychol Addict Behav Date: 2021-05-06
Authors: Marian Sarala; Antti Mustonen; Anni-Emilia Alakokkare; Caroline Salom; Jouko Miettunen; Solja Niemelä Journal: Eur J Public Health Date: 2022-04-01 Impact factor: 4.424
Authors: Maarit K Koivisto; Jouko Miettunen; Jonna Levola; Antti Mustonen; Anni-Emilia Alakokkare; Caroline L Salom; Solja Niemelä Journal: Eur J Public Health Date: 2022-10-03 Impact factor: 4.424