| Literature DB >> 31755722 |
Jian-Guo Song1,2, Jun-Cheng Su1,2, Qiao-Yun Song1,2, Rui-Li Huang1,2, Wei Tang1,2, Li-Jun Hu1,2, Xiao-Jun Huang1,2, Ren-Wang Jiang1,2, Yao-Lan Li1,2, Wen-Cai Ye1,2, Ying Wang1,2.
Abstract
Two novel phloroglucinol-terpenoid adducts (1 and 2), featuring a rare 2,2,4-trimethyl-cinnamyl-β-triketone unit, were isolated from the buds of Cleistocalyx operculatus. Their structures with absolute configurations were established by spectroscopic analyses, single-crystal X-ray diffraction, and quantum chemical calculations. Structurally, compound 1 represents a new carbon skeleton possessing a densely functionalized tricyclo[11.3.1.03;8]heptadecane bridged ring system with an unusual bridgehead enol. Compounds 1 and 2 exhibited significant in vitro antiviral activities against respiratory syncytial virus (RSV).Entities:
Year: 2019 PMID： 31755722 DOI： 10.1021/acs.orglett.9b03743
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005