K L Parmar1,2,3, L Malcomson1,2,3, A G Renehan1,2,3. 1. Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. 2. Colorectal and Peritoneal Oncology Centre, The Christie NHS Foundation Trust, Manchester, UK. 3. Manchester Cancer Research Centre, National Institute for Health Research (NIHR) Manchester Biomedical Research Centre, Manchester, UK.