Yun Wen1, Jianhua Yan2,2, Zhonghao Wang1, Tao Shen1, Xuan Qiu1, Daming Deng1, Jingchang Chen1. 1. The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. 2. The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China. yanjh2011@126.com.
Abstract
PURPOSE: Investigate morphological changes of macula and optic nerve head (ONH) in concomitant strabismic patients using optical coherence tomography (OCT) and confocal scanning laser ophthalmoscopy (CSLO). METHODS: A cross-sectional study conducted from April 2017 to February 2018 at the Zhongshan Ophthalmic Center, Sun Yat-sen University. Spectral-domain (SD)-OCT and CSLO were used to observe morphological changes of macula and ONH in concomitant strabismic patients with normal vision and healthy controls. In each subject, a 6-mm diameter zone centered at the fovea was scanned and topographical images of the ONH and peripapillary retina were generated. Fundus parameters were recorded and analyzed. RESULTS: A total of 138 cases, including 29 patients with concomitant esotropia (ET), 38 constant exotropia (XT), 42 intermittent exotropia (IXT), and 29 healthy controls, were recruited. Compared with controls, OCT revealed that the thickness of nasal intraretinal layers (IRLs) in ET patients was significantly increased, particularly in ganglion cell layer (GCL) and inner nuclear layer (INL). In XT patients, the temporal half of outer retinal layers (ORLs) showed significant increases in thickness. CSLO findings revealed significant changes in the ONH of ET patients consisting of a thinner retinal nerve fiber layer (RNFL) and a decreased RNFL cross-sectional area, height variation contour, maximum contour depression, and contour line modulation (CLM) temporal-superior area. The nasal-superior cup area and rim volume in XT patients were significantly increased. CONCLUSION: Topographical profiles of the macula and ONH in concomitant strabismic patients with normal vision present with specific regularities.
PURPOSE: Investigate morphological changes of macula and optic nerve head (ONH) in concomitant strabismic patients using optical coherence tomography (OCT) and confocal scanning laser ophthalmoscopy (CSLO). METHODS: A cross-sectional study conducted from April 2017 to February 2018 at the Zhongshan Ophthalmic Center, Sun Yat-sen University. Spectral-domain (SD)-OCT and CSLO were used to observe morphological changes of macula and ONH in concomitant strabismic patients with normal vision and healthy controls. In each subject, a 6-mm diameter zone centered at the fovea was scanned and topographical images of the ONH and peripapillary retina were generated. Fundus parameters were recorded and analyzed. RESULTS: A total of 138 cases, including 29 patients with concomitant esotropia (ET), 38 constant exotropia (XT), 42 intermittent exotropia (IXT), and 29 healthy controls, were recruited. Compared with controls, OCT revealed that the thickness of nasal intraretinal layers (IRLs) in ET patients was significantly increased, particularly in ganglion cell layer (GCL) and inner nuclear layer (INL). In XT patients, the temporal half of outer retinal layers (ORLs) showed significant increases in thickness. CSLO findings revealed significant changes in the ONH of ET patients consisting of a thinner retinal nerve fiber layer (RNFL) and a decreased RNFL cross-sectional area, height variation contour, maximum contour depression, and contour line modulation (CLM) temporal-superior area. The nasal-superior cup area and rim volume in XT patients were significantly increased. CONCLUSION: Topographical profiles of the macula and ONH in concomitant strabismic patients with normal vision present with specific regularities.
Authors: Zahra Hussain; Carl-Magnus Svensson; Julien Besle; Ben S Webb; Brendan T Barrett; Paul V McGraw Journal: J Vis Date: 2015-02-26 Impact factor: 2.240
Authors: Andrea Szigeti; Erika Tátrai; Anna Szamosi; Péter Vargha; Zoltán Zsolt Nagy; János Németh; Delia Cabrera DeBuc; Gábor Márk Somfai Journal: PLoS One Date: 2014-02-06 Impact factor: 3.240