Catharina J Alberts1, Isabelle Heard2,3, Ana Canestri4, Lucie Marchand5, Jean-François Fléjou6,7, Lionel Piroth8,9, Tristan Ferry10, Jean-Michel Didelot11, Laurent Siproudhis12,13,14, Sébastien Henno15, Isabelle Poizot-Martin16,17, Teresa M Darragh18, Gary M Clifford1, Jean-Damien Combes1, Isabelle Etienney19. 1. International Agency for Research on Cancer, Lyon, France. 2. Centre National de Référence des HPV, Institut Pasteur, Paris, France. 3. Hôpital Tenon, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France. 4. Service des Maladies Infectieuses et Tropicales, Hôpital Tenon, AP-HP, Paris, France. 5. ANRS (France Recherche Nord et Sud Sida-HIV et Hépatites), Paris, France. 6. Service d'Anatomie et Cytologie Pathologiques, Hôpital Saint-Antoine, Groupe Hospitalier Hôpitaux Universitaires Est Parisien (GH HUEP), AP-HP, Paris, France. 7. Faculté de Médecine Sorbonne Université, Paris, France. 8. Département d'Infectiologie, Centre Hospitalier Universitaire (CHU) de Dijon, Dijon, France. 9. Institut National de la Sante et de la Recherche Medicale (INSERM) Centre d'Investigation Clinique (CIC) 1432, Université de Bourgogne, Dijon, France. 10. Département d'Infectiologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France. 11. Département d'Hépato-Gastroentérologie, CHU Saint Eloi et Université de Montpellier, Montpellier, France. 12. Department of Gastroenterology, University Hospital of Rennes, Pontchaillou, Rennes, France. 13. INSERM U1241, University of Rennes 1, Rennes, France. 14. INPHY CIC 1414 University Hospital of Rennes, Pontchaillou, Rennes, France. 15. Service d'Anatomie et Cytologie Pathologiques, CHU Pontchaillou, Rennes, France. 16. Service d'Immuno-Hématologie Clinique, Université Aix Marseille, APHM Sainte-Marguerite, Marseille, France. 17. INSERM U912 (Sciences économiques et sociales de la santé et traitement de l'information médicale - SESSTIM), Marseille, France. 18. Department of Pathology, University of California San Francisco, San Francisco, California, USA. 19. Service de Proctologie Médico-Interventionnelle, Groupe Hospitalier Diaconesses Croix-Saint-Simon, Paris, France.
Abstract
BACKGROUND: Prospective data on the natural history of anal human papillomavirus (HPV) infection are scarce in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). METHODS: We analyzed incidence and clearance of HPV-16 and HPV-18 in a French cohort of HIV-infected MSM, aged ≥35 years, followed-up annually (n = 438, 2014-2018). RESULTS: Human papillomavirus-16 and HPV-18 incidence were similar (~10% incident infections at 24 months). Human papillomavirus-16 incidence was higher among high-grade versus no lesion at baseline (adjusted incidence rate ratio = 3.0; 95% confidence interval, 1.07-8.18). Human papillomavirus-16 cleared significantly slower than HPV-18 (32% versus 54% by 24 months). CONCLUSIONS: In conclusion, anal HPV-16 is more persistent than HPV-18, and its incidence correlates with a prior detection of high-grade lesions.
BACKGROUND: Prospective data on the natural history of anal human papillomavirus (HPV) infection are scarce in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). METHODS: We analyzed incidence and clearance of HPV-16 and HPV-18 in a French cohort of HIV-infected MSM, aged ≥35 years, followed-up annually (n = 438, 2014-2018). RESULTS: Human papillomavirus-16 and HPV-18 incidence were similar (~10% incident infections at 24 months). Human papillomavirus-16 incidence was higher among high-grade versus no lesion at baseline (adjusted incidence rate ratio = 3.0; 95% confidence interval, 1.07-8.18). Human papillomavirus-16 cleared significantly slower than HPV-18 (32% versus 54% by 24 months). CONCLUSIONS: In conclusion, anal HPV-16 is more persistent than HPV-18, and its incidence correlates with a prior detection of high-grade lesions.
Authors: Carmen Hidalgo-Tenorio; Carmen Maria García-Martínez; Juan Pasquau; Mohamed Omar-Mohamed-Balgahata; Miguel López-Ruz; Javier López-Hidalgo; Concepción Gil-Anguita Journal: PLoS One Date: 2021-02-03 Impact factor: 3.240
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Authors: Ian K J Wong; Isobel Mary Poynten; Alyssa Cornall; David J Templeton; Monica Molano; Suzanne M Garland; Christopher K Fairley; Carmella Law; Richard J Hillman; Mark N Polizzotto; Andrew E Grulich; Fengyi Jin Journal: Sex Transm Infect Date: 2021-03-16 Impact factor: 3.519