| Literature DB >> 31753251 |
Billel Gasmi1, David E Kleiner2.
Abstract
When patients with suspected drug-induced liver injury (DILI) undergo liver biopsy, the pathologist can provide a wealth of information on the morphologic changes. The most common histologic patterns of DILI include mimics of acute and chronic hepatitis as well as acute cholestasis, chronic cholestasis, and a mixed pattern that combines hepatitis with cholestasis. The pattern may suggest etiologies of injury or correlate with reported patterns of injury for specific agents. Biopsy may exonerate or indict particular drugs as causal agents of injury and provide specific information on severity of injury and specific types of changes related to various outcomes. Published by Elsevier Inc.Entities:
Keywords: Acute hepatitis; Cholestatic hepatitis; Hepatic necrosis; Hepatotoxicity; Nodular regenerative hyperplasia
Mesh:
Year: 2019 PMID: 31753251 PMCID: PMC6986808 DOI: 10.1016/j.cld.2019.09.004
Source DB: PubMed Journal: Clin Liver Dis ISSN: 1089-3261 Impact factor: 6.126