| Literature DB >> 31752338 |
Yang Zhao1,2, Ajay Singh Mahal1, Tilahun Nigatu Haregu1,2, Ameera Katar1, Brian Oldenburg1,2, Luwen Zhang3.
Abstract
Background: Hypertension is one of the most significant and common risk factors for cardiovascular disease, yet it remains poorly controlled in China. This study aims to examine trends and socioeconomic inequalities in the management of hypertension between 2011 and 2015 in China and to investigate the association between antihypertensive medication treatment and reduction of blood pressure, using nationally representative data.Entities:
Keywords: China; healthcare; hypertension; socioeconomic inequality; trends
Mesh:
Substances:
Year: 2019 PMID: 31752338 PMCID: PMC6888605 DOI: 10.3390/ijerph16224578
Source DB: PubMed Journal: Int J Environ Res Public Health ISSN: 1660-4601 Impact factor: 3.390
Definition of indicators for evaluating the management of hypertension.
| Measures | Definition |
|---|---|
| Prevalence | Systolic blood pressure ≥140 mmHg and/or diastolic blood pressure≥90 mmHg and/or self-reported antihypertensive medication use at the time of the investigation |
| Hypertension care | |
| Awareness | Hypertensive persons who reported the doctor's diagnosis of hypertension previously or current use of antihypertensive medication |
| Treatment | Identified hypertensive adults who reported current use of antihypertensive medication |
| Control | Identified hypertensive adults whose systolic blood pressure was <140 mmHg and whose diastolic blood pressure was <90 mmHg |
| Health service utilisation | |
| Outpatient visit | ‘In the last month have you visited a public hospital, private hospital, public health centre, clinic, or doctor’s practice, or been visited by a doctor for outpatient care?’ |
| Inpatient visit | ‘Have you received inpatient care in the past year?’ |
| Health education | Health education provided by health professionals, which includes weight control, exercise, healthy diet and aspects of smoking control |
Note: In the calculation of hypertension prevalence, the denominator was the number of all respondents; in the calculation of the percentage of awareness, treatment and blood pressure control, the denominator was the number of all identified hypertensive patients.
Prevalence and healthcare of hypertension among adults 45 years and above in China from 2011 to 2015.
| 2011 | 2013 | 2015 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | Unweighted | Weighted | N | Unweighted | Weighted | N | Unweighted | Weighted | ||
| Total population | 13,725 | 100.00 | 100.00 | 10,893 | 100.00 | 100.00 | 11,675 | 100.00 | 100.00 | |
| Prevalence | 5285 | 38.51 | 40.78 | 4666 | 42.83 | 43.25 | 4874 | 41.75 | 41.81 | <0.001 |
| Among people with hypertension | ||||||||||
| Awareness | 2976 | 56.31 | 55.87 | 2876 | 61.64 | 60.04 | 3316 | 68.03 | 68.31 | <0.001 |
| Without comorbidity | 755 | 43.07 | 42.19 | 598 | 46.39 | 44.48 | 734 | 54.29 | 55.80 | <0.001 |
| With comorbidity | 2221 | 62.88 | 63.38 | 2278 | 67.46 | 66.77 | 2582 | 73.31 | 73.32 | <0.001 |
| Medication treatment | 2579 | 48.80 | 48.44 | 2485 | 53.26 | 52.57 | 2980 | 61.14 | 61.97 | <0.001 |
| Without comorbidity | 638 | 36.39 | 35.40 | 473 | 36.70 | 36.39 | 645 | 47.71 | 49.59 | <0.001 |
| With comorbidity | 1941 | 54.95 | 55.60 | 2012 | 59.58 | 59.56 | 2335 | 66.30 | 66.93 | <0.001 |
| Blood pressure control | 1072 | 20.28 | 19.34 | 1064 | 22.80 | 22.19 | 1326 | 27.21 | 28.57 | <0.001 |
| Without comorbidity | 250 | 14.26 | 13.24 | 189 | 14.66 | 12.79 | 268 | 19.82 | 22.96 | <0.001 |
| With comorbidity | 822 | 23.27 | 22.69 | 875 | 25.91 | 26.25 | 1058 | 30.04 | 30.81 | <0.001 |
Note: Unweighted values referred to the results of calculating direct observations and weighted values referred to the results after adjusting the sampling design and nonresponding cases. p values are reported for intertemporal differences of the weighted proportion; in the calculation of the percentage of awareness, treatment and BP control, the denominator was the number of all identified hypertensive patients.
Trends in the health service use among people with hypertension by comorbidity status in China from 2011 to 2015.
| Health Service Use | 2011 | 2013 | 2015 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | Unweighted | Weighted | N | Unweighted | Weighted | N | Unweighted | Weighted | ||
| Proportion of outpatient visit | 1029 | 19.72 | 21.24 | 1084 | 23.60 | 23.38 | 988 | 20.62 | 20.60% | 0.105 |
| Without comorbidity | 200 | 11.53 | 13.65 | 166 | 12.98 | 13.16 | 179 | 13.44 | 14.21% | 0.692 |
| With comorbidity | 829 | 23.81 | 25.43 | 918 | 27.70 | 27.84 | 809 | 23.39 | 23.18% | 0.226 |
| Proportion of inpatient visit | 577 | 10.93 | 10.68 | 754 | 16.19 | 17.68 | 861 | 17.72 | 17.41% | <0.001 |
| Without comorbidity | 100 | 5.72 | 5.62 | 93 | 7.24 | 14.73 | 154 | 11.44 | 11.82% | <0.001 |
| With comorbidity | 477 | 13.51 | 13.45 | 661 | 19.60 | 18.95 | 707 | 20.12 | 19.66% | <0.001 |
| Proportion of health education | 1717 | 32.49 | 33.67 | 1713 | 36.71 | 36.55 | 1942 | 39.84 | 39.79% | <0.001 |
| Without comorbidity | 388 | 22.13 | 22.87 | 280 | 21.72 | 22.54 | 413 | 30.55 | 30.37% | <0.001 |
| With comorbidity | 1329 | 37.63 | 39.59 | 1433 | 42.43 | 42.60 | 1529 | 43.41 | 43.57% | <0.001 |
Note: Unweighted values referred to the results of calculating direct observations and weighted values referred to the results after adjusting the sampling design and nonresponding cases. p values are reported for intertemporal differences of the weighted proportion; health education provided by health professionals includes weight control, exercise, healthy diet and aspects of smoking control.
Healthcare for hypertensive adults in China across wealth quintiles and concentration indexes, 2015.
| Wealth Group, PCE | Awareness | Medication Treatment | BP Control | Outpatient Visit | Inpatient | Health Education |
|---|---|---|---|---|---|---|
| 1st (Poorest) | 64.82% | 57.71% | 24.28% | 17.41% | 8.01% | 31.63% |
| 2nd (Poor) | 65.43% | 59.88% | 27.99% | 21.41% | 14.28% | 41.68% |
| 3rd (Middle) | 71.04% | 63.52% | 32.14% | 17.84% | 17.67% | 46.70% |
| 4th (Rich) | 74.42% | 65.07% | 30.86% | 18.86% | 19.08% | 47.20% |
| 5th (Richest) | 71.97% | 66.66% | 34.32% | 25.65% | 23.27% | 42.95% |
| Ratio (Richest/Poorest) | 1.11 | 1.16 | 1.41 | 1.47 | 2.91 | 1.36 |
| CIc | 0.007 | 0.010 | 0.008 | 0.033 | 0.086 *** | −0.004 |
Note: PCE, per capita household annual consumption expenditure; BP, blood pressure; Health education provided by health professionals includes weight control, exercise, healthy diet and aspects of smoking control. The proportions reported are weighted values. *** p < 0.001, ** p < 0.01, * p < 0.05 significance test.
Figure 1Concentration curves of healthcare for adults with hypertension in China in 2015.
Figure 2Concentration curves of health service use for adults with hypertension in China in 2015.
Fixed-effects analysis of the relationship between antihypertensive medication treatment and blood pressure control.
| Variable (Reference) | SBP-Model 1 | SBP-Model 2 | DBP-Model 1 | DBP-Model 2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | |||||
| Main effects | ||||||||||||
| Treatment (no) | −13.483 | −15.672 | −11.293 | −16.115 | −28.382 | −3.848 | −5.367 | −6.390 | −4.344 | −8.326 | −14.048 | −2.604 |
| Age | −0.386 | −0.674 | −0.097 | −0.388 | −0.677 | −0.100 | −0.121 | −0.255 | 0.013 | −0.121 | −0.255 | 0.013 |
| PCE, Quintile 1st | ||||||||||||
| 2nd | −3.125 | −5.419 | −0.830 | −1.736 | −5.400 | 1.928 | −0.508 | −1.576 | 0.560 | −0.002 | −1.710 | 1.707 |
| 3rd | 0.025 | −2.338 | 2.388 | 2.094 | −1.664 | 5.853 | −0.215 | −1.316 | 0.885 | 0.150 | −1.604 | 1.903 |
| 4th | 0.313 | −2.179 | 2.806 | 2.757 | −1.035 | 6.548 | −0.231 | −1.392 | 0.931 | −0.441 | −2.213 | 1.331 |
| 5th | −2.066 | −4.740 | 0.608 | −0.190 | −4.574 | 4.193 | −0.197 | −1.442 | 1.047 | 0.402 | −1.642 | 2.446 |
| BMI | 0.126 | −0.221 | 0.474 | 0.005 | −0.448 | 0.457 | 0.175 | 0.013 | 0.336 | 0.084 | −0.126 | 0.295 |
| Comorbidity (no) | −1.353 | −4.980 | 2.275 | −1.400 | −5.839 | 3.039 | −1.853 | −3.545 | −0.162 | −1.596 | −3.673 | 0.481 |
| Smoking (no) | 3.492 | −0.586 | 7.569 | 3.327 | −0.759 | 7.413 | 0.130 | −1.773 | 2.032 | 0.133 | −1.773 | 2.040 |
| Drinking (no) | 1.527 | −1.084 | 4.139 | 1.512 | −1.101 | 4.125 | 0.980 | −0.236 | 2.196 | 0.975 | −0.242 | 2.192 |
| Interaction effects | ||||||||||||
| Treatment × PCE | ||||||||||||
| Treatment × 2nd | −2.381 | −7.080 | 2.318 | −0.815 | −3.006 | 1.376 | ||||||
| Treatment × 3rd | −3.459 | −8.169 | 1.251 | −0.629 | −2.824 | 1.566 | ||||||
| Treatment × 4th | −4.090 | −8.879 | 0.698 | 0.353 | −1.882 | 2.587 | ||||||
| Treatment × 5th | −3.078 | −8.323 | 2.167 | −0.885 | −3.329 | 1.559 | ||||||
| Treatment × BMI | 0.204 | −0.262 | 0.670 | 0.146 | −0.072 | 0.363 | ||||||
| Treatment × Comorbidity | 0.134 | −4.080 | 4.348 | −0.423 | −2.396 | 1.550 | ||||||
| Constant | 176.336 | 156.896 | 195.776 | 178.044 | 157.463 | 198.625 | 91.426 | 82.380 | 100.471 | 93.207 | 83.630 | 102.784 |
Note: SBP, systolic blood pressure; DBP, diastolic blood pressure; PCE, per capita household annual consumption expenditure; BMI, body mass index; 95% CI, 95% confidence interval. All models were adjusted for age, living standard, BMI, comorbidity, smoking and drinking alcohol. Models 1 included only main-effects terms for all variables; Models 2 included both main-effects terms and interaction-effects terms for treatment and household consumption expenditure, BMI and comorbidity. × refers to the interaction term.