Literature DB >> 31751895

Molecular Pharming for low and middle income countries.

Sheeba Murad1, Sebastian Fuller1, Jonathan Menary1, Cathy Moore1, Elizabeth Pinneh1, Tim Szeto1, Inga Hitzeroth2, Marcos Freire3, Suthira Taychakhoonavudh4, Waranyoo Phoolcharoen5, Julian K-C Ma6.   

Abstract

Interest in applications and benefits that Molecular Pharming might offer to Low and Middle Income Countries has always been a potent driver for the research discipline, and a major reason why many scientists entered the field. Although enthusiasm remains high, the reality is that such a game-changing innovation would always take longer than traditional uptake of new technology in developed countries, and be complicated by external factors beyond technical feasibility. Excitingly, signs of increasing interest by LMICS in Molecular Pharming are now emerging. Here, three case studies from Thailand, South Africa and Brazil are used to identify some of the key issues when a new investment into Molecular Pharming manufacturing capacity is under consideration. At present, academic research is not necessarily addressing these issues. Only by understanding the concerns, can members of the academic community contribute to helping the development of Molecular Pharming for LMICs by focusing their research efforts appropriately.
Copyright © 2019. Published by Elsevier Ltd.

Year:  2019        PMID: 31751895     DOI: 10.1016/j.copbio.2019.10.005

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN: 0958-1669            Impact factor:   9.740


  14 in total

1.  New Hope for a "Cursed" Crop? Understanding Stakeholder Attitudes to Plant Molecular Farming With Modified Tobacco in Europe.

Authors:  Jonathan Menary; Mario Amato; Andrés Cid Sanchez; Matthew Hobbs; Agata Pacho; Sebastian S Fuller
Journal:  Front Plant Sci       Date:  2020-06-12       Impact factor: 5.753

Review 2.  A Roadmap for the Molecular Farming of Viral Glycoprotein Vaccines: Engineering Glycosylation and Glycosylation-Directed Folding.

Authors:  Emmanuel Margolin; Max Crispin; Ann Meyers; Ros Chapman; Edward P Rybicki
Journal:  Front Plant Sci       Date:  2020-12-03       Impact factor: 5.753

3.  Alfalfa Plants (Medicago sativa L.) Expressing the 85B (MAP1609c) Antigen of Mycobacterium avium subsp. paratuberculosis Elicit Long-Lasting Immunity in Mice.

Authors:  Elizabeth Monreal-Escalante; Cristhian Sández-Robledo; Amalia León-Gallo; Virginie Roupie; Kris Huygen; Sawako Hori-Oshima; Mario Arce-Montoya; Sergio Rosales-Mendoza; Carlos Angulo
Journal:  Mol Biotechnol       Date:  2021-03-02       Impact factor: 2.695

4.  Shotguns vs Lasers: Identifying barriers and facilitators to scaling-up plant molecular farming for high-value health products.

Authors:  Jonathan Menary; Matthew Hobbs; Sara Mesquita de Albuquerque; Agata Pacho; Pascal M W Drake; Alison Prendiville; Julian K-C Ma; Sebastian S Fuller
Journal:  PLoS One       Date:  2020-03-20       Impact factor: 3.240

Review 5.  Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development.

Authors:  Balamurugan Shanmugaraj; Ashwini Malla; Waranyoo Phoolcharoen
Journal:  Pathogens       Date:  2020-02-22

Review 6.  Prospects for SARS-CoV-2 diagnostics, therapeutics and vaccines in Africa.

Authors:  Emmanuel Margolin; Wendy A Burgers; Edward D Sturrock; Marc Mendelson; Rosamund Chapman; Nicola Douglass; Anna-Lise Williamson; Edward P Rybicki
Journal:  Nat Rev Microbiol       Date:  2020-09-10       Impact factor: 60.633

7.  Investigating Constraints Along the Plant Secretory Pathway to Improve Production of a SARS-CoV-2 Spike Vaccine Candidate.

Authors:  Emmanuel Margolin; Matthew Verbeek; Warren de Moor; Ros Chapman; Ann Meyers; Georgia Schäfer; Anna-Lise Williamson; Edward Rybicki
Journal:  Front Plant Sci       Date:  2022-01-04       Impact factor: 5.753

8.  A plant-biotechnology approach for producing highly potent anti-HIV antibodies for antiretroviral therapy consideration.

Authors:  Advaita Acarya Singh; Priyen Pillay; Lusisizwe Kwezi; Tsepo Lebiletsa Tsekoa
Journal:  J Genet Eng Biotechnol       Date:  2021-12-08

Review 9.  Contributions of the international plant science community to the fight against human infectious diseases - part 1: epidemic and pandemic diseases.

Authors:  Maria Lobato Gómez; Xin Huang; Derry Alvarez; Wenshu He; Can Baysal; Changfu Zhu; Victoria Armario-Najera; Amaya Blanco Perera; Pedro Cerda Bennasser; Andera Saba-Mayoral; Guillermo Sobrino-Mengual; Ashwin Vargheese; Rita Abranches; Isabel Alexandra Abreu; Shanmugaraj Balamurugan; Ralph Bock; Johannes F Buyel; Nicolau B da Cunha; Henry Daniell; Roland Faller; André Folgado; Iyappan Gowtham; Suvi T Häkkinen; Shashi Kumar; Sathish Kumar Ramalingam; Cristiano Lacorte; George P Lomonossoff; Ines M Luís; Julian K-C Ma; Karen A McDonald; Andre Murad; Somen Nandi; Barry O'Keefe; Kirsi-Marja Oksman-Caldentey; Subramanian Parthiban; Mathew J Paul; Daniel Ponndorf; Elibio Rech; Julio C M Rodrigues; Stephanie Ruf; Stefan Schillberg; Jennifer Schwestka; Priya S Shah; Rahul Singh; Eva Stoger; Richard M Twyman; Inchakalody P Varghese; Giovanni R Vianna; Gina Webster; Ruud H P Wilbers; Teresa Capell; Paul Christou
Journal:  Plant Biotechnol J       Date:  2021-07-19       Impact factor: 13.263

10.  Characterisation of a highly potent and near pan-neutralising anti-HIV monoclonal antibody expressed in tobacco plants.

Authors:  Catherine M Moore; Melanie Grandits; Clemens Grünwald-Gruber; Friedrich Altmann; Maria Kotouckova; Audrey Y-H Teh; Julian K-C Ma
Journal:  Retrovirology       Date:  2021-06-28       Impact factor: 4.602

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