Antioxidant, anti-inflammatory and renoprotective effects of acidic-hydrolytic polysaccharides by spent mushroom compost (Lentinula edodes) on LPS-induced kidney injury.

Increasing evidences have demonstrated that the reactive oxygen species play important roles in the initiation and progress of LPS-induced kidney injury (KI). The present work investigated the antioxidant, anti-inflammatory and renoprotective effects of acidic spent mushroom compost polysaccharides (ASMCP) by Lentinula edodes against the LPS-induced KI in mice. The results demonstrated that ASMCP showed anti-inflammatory effects on reducing the serum levels of TNF-α, IL-6 and IL-1β, inhibiting the elevation of lipid peroxidation, lowering the serum levels of BUN, CRE and UA, and improving the antioxidant status by enhancing renal enzyme activities (SOD, GSH-Px, CAT and T-AOC). Furthermore, the histological observations of renal cortex and renal medulla also indicated the potential renoprotective effects of ASMCP. These conclusions suggested that ASMCP might be suitable for functional foods and a potentially effective candidate medicine for the treatment of KI.