Jee-Eun Kim1, Sang-Hyun Park2, Kyungdo Han2, Ho Jin Kim3, Dong-Wook Shin4, Sung-Min Kim5. 1. Department of Neurology, Seoul Medical Center, Seoul, Korea. 2. Department of Medical Statistics, College of Medicine, The Catholic University of Korea, Seoul, Korea. 3. Department of Neurology, National Cancer Center, Goyang, Korea. 4. Departments of Family Medicine and Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea/Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, Korea. 5. Department of Neurology, Seoul National University Hospital, Seoul, Korea/Department of Neurology, Seoul National University, College of Medicine, Seoul, Korea.
Abstract
BACKGROUND: The epidemiology of neuromyelitis optica spectrum disorder and multiple sclerosis varies depending on the region and ethnicity. OBJECTIVE: To estimate the prevalence and incidence of neuromyelitis optica spectrum disorder and multiple sclerosis in Korea during 2010-2016. METHODS: We analyzed the National Health Insurance research database, which contains single-payer health insurance data collected in Korea. Neuromyelitis optica spectrum disorder was defined based on the 2006 Wingerchuk criteria (for 2010-2015), and the 2015 International Panel for Neuromyelitis Optica Diagnosis criteria (for 2016). Multiple sclerosis was defined by the 2005 International Panel criteria for multiple sclerosis. RESULTS: In 2016, the age-standardized prevalence per 100,000 persons was 2.56 (95% confidence interval: 2.43-2.7) for neuromyelitis optica spectrum disorder and 3.23 (95% confidence interval: 3.08-3.39) for multiple sclerosis. The age-standardized incidence of neuromyelitis optica spectrum disorder and multiple sclerosis were 0.73 (95% confidence interval: 0.66-0.8) and 0.50 (95% confidence interval: 0.44-0.56) per 100,000 persons in 2016. The prevalence of neuromyelitis optica spectrum disorder and multiple sclerosis have increased over time during 2010-2016 (18.5% and 5.4% annually; both p-trend < 0.001). The incidence of neuromyelitis optica spectrum disorder increased annually (10.0%, p-trend < 0.001), while the incidence of multiple sclerosis remained stable. CONCLUSION: While the prevalence of neuromyelitis optica spectrum disorder and multiple sclerosis are comparable in Korea, the incidence of neuromyelitis optica spectrum disorder is higher than that of multiple sclerosis. Both the prevalence and incidence of neuromyelitis optica spectrum disorder are rapidly increasing in Korea.
BACKGROUND: The epidemiology of neuromyelitis optica spectrum disorder and multiple sclerosis varies depending on the region and ethnicity. OBJECTIVE: To estimate the prevalence and incidence of neuromyelitis optica spectrum disorder and multiple sclerosis in Korea during 2010-2016. METHODS: We analyzed the National Health Insurance research database, which contains single-payer health insurance data collected in Korea. Neuromyelitis optica spectrum disorder was defined based on the 2006 Wingerchuk criteria (for 2010-2015), and the 2015 International Panel for Neuromyelitis Optica Diagnosis criteria (for 2016). Multiple sclerosis was defined by the 2005 International Panel criteria for multiple sclerosis. RESULTS: In 2016, the age-standardized prevalence per 100,000 persons was 2.56 (95% confidence interval: 2.43-2.7) for neuromyelitis optica spectrum disorder and 3.23 (95% confidence interval: 3.08-3.39) for multiple sclerosis. The age-standardized incidence of neuromyelitis optica spectrum disorder and multiple sclerosis were 0.73 (95% confidence interval: 0.66-0.8) and 0.50 (95% confidence interval: 0.44-0.56) per 100,000 persons in 2016. The prevalence of neuromyelitis optica spectrum disorder and multiple sclerosis have increased over time during 2010-2016 (18.5% and 5.4% annually; both p-trend < 0.001). The incidence of neuromyelitis optica spectrum disorder increased annually (10.0%, p-trend < 0.001), while the incidence of multiple sclerosis remained stable. CONCLUSION: While the prevalence of neuromyelitis optica spectrum disorder and multiple sclerosis are comparable in Korea, the incidence of neuromyelitis optica spectrum disorder is higher than that of multiple sclerosis. Both the prevalence and incidence of neuromyelitis optica spectrum disorder are rapidly increasing in Korea.
Authors: Hye Lim Lee; Jae Young Kim; Jin Myoung Seok; Yoon Ho Hong; Nam Gu Lim; Ha Young Shin; Byung Jo Kim; Soon Young Hwang; Ju Hong Min; Byoung Joon Kim Journal: J Korean Med Sci Date: 2020-05-04 Impact factor: 2.153