| Literature DB >> 31749244 |
Qi Teng1, Wenxiu Mao1, Dong Chen1, Zhen Wang1, Chen-Ho Tung1, Zhenghu Xu1,2.
Abstract
A rhodium(I)-BINAP-catalyzed highly enantioselective [2+2+2] cycloaddition of enynes with alkynes has been developed. Diverse fused tricyclic hydronaphthofuran scaffolds with three consecutive stereogenic centers were constructed in one step from easily available materials with excellent chemo-, regio-, diastereo-, and enantioselectivity. Notable features of these reactions include 100 % atom economy, very broad scope, and mild reaction conditions.Entities:
Keywords: asymmetric catalysis; cycloaddition; desymmetrization; homogeneous catalysis; rhodium
Year: 2019 PMID： 31749244 DOI： 10.1002/anie.201911071
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336