Carlo Maj1,2, Sarah Tosato3, Roberta Zanardini4, Antonio Lasalvia5, Angela Favaro6, Emanuela Leuci7, Giovanni De Girolamo8, Mirella Ruggeri3, Massimo Gennarelli2,9, Luisella Bocchio-Chiavetto2,10. 1. Institute for Genomic Statistics and Bioinformatics, University Hospital, Bonn, Germany. 2. Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. 3. Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Italy. 4. Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. 5. UOC Psichiatria, Azienda Ospedaliera Universitaria Integrata (AOUI) di Verona, Verona, Italy. 6. Department of Neurosciences, University of Padua and Azienda Ospedaliera, Padua, Italy. 7. Department of Mental Health, Parma, Italy. 8. Psychiatric Epidemiology and Evaluation Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. 9. Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Italy. 10. Faculty of Psychology, eCampus University, Novedrate (Como), Italy.
Abstract
AIMS: There is a strong interest in identifying the biological mechanisms involved in the genetic risk for psychotic disorders. In this study, we evaluated the correlation between serum concentrations of specific molecular markers and the genetic component for schizophrenia and bipolar disorder. METHODS: We analysed the association between the polygenic risk score (PRS) and the serum levels of different inflammatory/metabolic markers in a sample of 81 first-episode psychosis patients (FEP) with a diagnosis of schizophrenia or bipolar disorder and 33 controls. RESULTS: A positive correlation of schizophrenia and bipolar disorder PRS with the inflammatory marker C-C Motif Chemokine Ligand 4 serum concentration (ρ = 0.42, P = 1.56 × 10-04 and ρ = 0.40, P = 1.65 × 10-03 , respectively) and a negative correlation with the serum ghrelin content (ρ = - 0.35, P = 4.27 × 10-03 and ρ = - 0.45, P = 6.05 × 10-04 , respectively) were observed. CONCLUSION: These findings provide new insight into the biological underpinnings of the PRS component, thus supporting a role of the genetic liability on the inflammatory and metabolic alterations that characterize psychosis onset.
AIMS: There is a strong interest in identifying the biological mechanisms involved in the genetic risk for psychotic disorders. In this study, we evaluated the correlation between serum concentrations of specific molecular markers and the genetic component for schizophrenia and bipolar disorder. METHODS: We analysed the association between the polygenic risk score (PRS) and the serum levels of different inflammatory/metabolic markers in a sample of 81 first-episode psychosispatients (FEP) with a diagnosis of schizophrenia or bipolar disorder and 33 controls. RESULTS: A positive correlation of schizophrenia and bipolar disorder PRS with the inflammatory marker C-C Motif Chemokine Ligand 4 serum concentration (ρ = 0.42, P = 1.56 × 10-04 and ρ = 0.40, P = 1.65 × 10-03 , respectively) and a negative correlation with the serum ghrelin content (ρ = - 0.35, P = 4.27 × 10-03 and ρ = - 0.45, P = 6.05 × 10-04 , respectively) were observed. CONCLUSION: These findings provide new insight into the biological underpinnings of the PRS component, thus supporting a role of the genetic liability on the inflammatory and metabolic alterations that characterize psychosis onset.
Authors: Lusi Zhang; Paulo Lizano; Bin Guo; Yanxun Xu; Leah H Rubin; S Kristian Hill; Ney Alliey-Rodriguez; Adam M Lee; Baolin Wu; Sarah K Keedy; Carol A Tamminga; Godfrey D Pearlson; Brett A Clementz; Matcheri S Keshavan; Elliot S Gershon; John A Sweeney; Jeffrey R Bishop Journal: Brain Behav Immun Health Date: 2022-04-08
Authors: Elina Sormunen; Maiju M Saarinen; Raimo K R Salokangas; Nina Hutri-Kähönen; Jorma Viikari; Olli T Raitakari; Jarmo Hietala Journal: Schizophrenia (Heidelb) Date: 2022-10-11