| Literature DB >> 31747749 |
Olga O Zaytseva1, Maxim B Freidin2, Toma Keser3, Jerko Štambuk1, Ivo Ugrina1,4, Mirna Šimurina3, Marija Vilaj1, Tamara Štambuk3, Irena Trbojević-Akmačić1, Maja Pučić-Baković1, Gordan Lauc1,3, Frances M K Williams2, Mislav Novokmet1.
Abstract
The N-glycosylation profile of total human plasma proteins could be a useful biomarker for various pathological states. Reliable high-throughput methods for such profiling have been developed. However, studies of relative importance of genetic and environmental factors in regulating plasma N-glycome are scarce. The aim of our study was to determine the role of genetic factors in phenotypic variation of plasma N-glycan profile through the estimates of its heritability. Thirty-nine total plasma N-glycome traits were analyzed in 2816 individuals from the TwinsUK data set. For the majority of the traits, high heritability estimates (>50%) were obtained pointing at a significant contribution of genetic factors in plasma N-glycome variation, especially for glycans mostly attached to immunoglobulins. We have also found several structures with higher environmental contribution to their variation.Entities:
Keywords: N-glycosylation; glycan analysis; heritability of glycosylation; human plasma glycome
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Year: 2019 PMID： 31747749 DOI： 10.1021/acs.jproteome.9b00348
Source DB: PubMed Journal: J Proteome Res ISSN： 1535-3893 Impact factor: 4.466