| Literature DB >> 31746551 |
M Rachele Ceccarini1, Anna Tasegian1, Marica Franzago2,3, F Filomena Patria1, Elisabetta Albi1, Michela Codini1, Carmela Conte1, Matteo Bertelli4, Laura Dalla Ragione5, Liborio Stuppia3,6, Tommaso Beccari1.
Abstract
Evidence from family and twin studies points to a genetic contribution to the etiology of eating disorders (EDs), confirmed by the association of several single nucleotide polymorphisms (SNPs) with this group of disorders. Previous reports have suggested that the serotonin receptor (5-HT2AR) and brain-derived neurotrophic factor (BDNF) genes could be both involved in EDs susceptibility. In order to provide further evidence about such association, we focused our attention on two SNPs located in these genes carrying out a genetic association study on a large Italian cohort composed of 556 ED patients and 355 controls (CTRs). Obtained results confirm the presence of an association between 5-HT2AR and BDNF genes and the susceptibility to EDs.Entities:
Keywords: zzm3219905-HT2AR; zzm321990BDNF; anorexia nervosa; binge eating; bulimia nervosa
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Year: 2019 PMID： 31746551 DOI： 10.1002/ajmg.b.32771
Source DB: PubMed Journal: Am J Med Genet B Neuropsychiatr Genet ISSN： 1552-4841 Impact factor: 3.568