Zidan Yu1,2,3, Guillaume Madelin1,2,3, Daniel K Sodickson1,2,3, Martijn A Cloos1,2,3. 1. Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York. 2. Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, New York. 3. The Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, New York.
Abstract
PURPOSE: The goal of this work is to demonstrate a method for the simultaneous acquisition of proton multiparametric maps (T1 , T2 , and proton density) and sodium density images in 1 single scan. We hope that the development of such capabilities will help to ease the implementation of sodium MRI in clinical trials and provide more opportunities for researchers to investigate metabolism through sodium MRI. METHODS: We developed a sequence based on magnetic resonance fingerprinting (MRF), which contains interleaved proton (1 H) and sodium (23 Na) excitations followed by a simultaneous center-out radial readout for both nuclei. The receive chain of a 7T scanner was modified to enable simultaneous acquisition of 1 H and 23 Na signal. The obtained signal-to-noise ratio (SNR) was evaluated, and the accuracy of both proton T1 , T2 , and B 1 + and sodium density maps were verified in phantoms. Finally, the method was demonstrated in 2 healthy subjects. RESULTS: The SNR obtained using the simultaneous measurement was almost identical to single-nucleus measurements (<1% change). Similarly, the proton T1 and T2 maps remained stable (normalized root mean square error in T1 ≈ 2.2%, in T2 ≈ 1.4%, and B 1 + ≈ 5.4%), which indicates that the proposed sequence and hardware have no significant effects on the signal from either nucleus. In vivo measurements corroborated these results and demonstrated the feasibility of our method for in vivo application. CONCLUSIONS: With the proposed approach, we were able to simultaneously acquire sodium density images in addition to proton T1 , T2 , and B 1 + maps as well as proton density images.
PURPOSE: The goal of this work is to demonstrate a method for the simultaneous acquisition of proton multiparametric maps (T1 , T2 , and proton density) and sodium density images in 1 single scan. We hope that the development of such capabilities will help to ease the implementation of sodium MRI in clinical trials and provide more opportunities for researchers to investigate metabolism through sodium MRI. METHODS: We developed a sequence based on magnetic resonance fingerprinting (MRF), which contains interleaved proton (1 H) and sodium (23 Na) excitations followed by a simultaneous center-out radial readout for both nuclei. The receive chain of a 7T scanner was modified to enable simultaneous acquisition of 1 H and 23 Na signal. The obtained signal-to-noise ratio (SNR) was evaluated, and the accuracy of both proton T1 , T2 , and B 1 + and sodium density maps were verified in phantoms. Finally, the method was demonstrated in 2 healthy subjects. RESULTS: The SNR obtained using the simultaneous measurement was almost identical to single-nucleus measurements (<1% change). Similarly, the proton T1 and T2 maps remained stable (normalized root mean square error in T1 ≈ 2.2%, in T2 ≈ 1.4%, and B 1 + ≈ 5.4%), which indicates that the proposed sequence and hardware have no significant effects on the signal from either nucleus. In vivo measurements corroborated these results and demonstrated the feasibility of our method for in vivo application. CONCLUSIONS: With the proposed approach, we were able to simultaneously acquire sodium density images in addition to proton T1 , T2 , and B 1 + maps as well as proton density images.
Authors: Armin M Nagel; Frederik B Laun; Marc-André Weber; Christian Matthies; Wolfhard Semmler; Lothar R Schad Journal: Magn Reson Med Date: 2009-12 Impact factor: 4.668
Authors: Debra F McGivney; Eric Pierre; Dan Ma; Yun Jiang; Haris Saybasili; Vikas Gulani; Mark A Griswold Journal: IEEE Trans Med Imaging Date: 2014-07-10 Impact factor: 10.048
Authors: Zidan Yu; Shota Hodono; Olga Dergachyova; Tom Hilbert; Bili Wang; Bei Zhang; Ryan Brown; Daniel K Sodickson; Guillaume Madelin; Martijn A Cloos Journal: Magn Reson Med Date: 2021-12-31 Impact factor: 4.668
Authors: Bili Wang; Bei Zhang; Zidan Yu; Carlotta Ianniello; Karthik Lakshmanan; Jan Paska; Guillaume Madelin; Martijn Cloos; Ryan Brown Journal: NMR Biomed Date: 2021-09-03 Impact factor: 4.478
Authors: Gonzalo G Rodriguez; Zidan Yu; Lauren F O Donnell; Liz Calderon; Martijn A Cloos; Guillaume Madelin Journal: Sci Rep Date: 2022-08-19 Impact factor: 4.996