Carbon fibers coated with urchin-like copper sulfide for nonenzymatic voltammetric sensing of glucose.

Urchin-like CuS was grown on xanthan gum-derived carbon nanofibers to obtain a sensor for enzyme-free electrochemical sensing of glucose. The unique nanostructure of the sensor provides a large specific surface, more electrocatalytically active sites, and high electrical conductivity. The voltammetric response to glucose, best measured at around 57 mV (vs. Ag/AgCl (E/V)) in 0.1 M NaOH solution, covers two linear ranges, one from 0.1-125 μM, another from 0.16 to 1.2 mM. The sensitivity is quite high (23.7 μA mM-1 cm-2), and the detection limit is low (19 nM at S/N = 3). The sensor has high selectivity against potentially interfering molecules such as fructose, appreciable operational stability, excellent durability, and good repeatability (with relative standard deviations of 2.3%). It was successfully applied to the determination of glucose in diluted serum samples. Graphical abstractSchematic representation of electrochemical detection of glucose based on the use of a screen printed carbon electrode (SPCE) modified with CuS and xanthan gum-derived carbon nanofibers (XGCNFs).