Literature DB >> 31745473

A 57-Year-Old Woman With Progressive Left Hand Clumsiness and Falls.

Vijayashankar Paramanandam1, Diana Angelika Olszewska1, Bhattacharjee Shakya2, Albi Jose Chalissery1, Martin O'Connell3, Michael Farrell4, Tim Lynch1.   

Abstract

CLINICAL HISTORY: A 57-year old woman presented with left hand pain, periodic leg movement during sleep, gradual onset of stiffness, clumsiness, and falls. Neurological examination showed: generalized rigidity and bradykinesia. There was left hand dystonic posturing and ideomotor apraxia, as well as mirror movements of upper limbs and stimulus-sensitive myoclonus. The patient had a high-pitched voice and hypophonia (Video S1). DISCUSSION: Experts discuss localization and the syndromic diagnosis and predict the underlying pathology. The pathological diagnosis is then provided and clinical learning points are considered.
© 2019 International Parkinson and Movement Disorder Society.

Entities:  

Keywords:  alpha‐synuclein; corticobasal syndrome; cytoplasmic inclusions; multisystem atrophy; myoclonus; parkinsonism

Year:  2019        PMID： 31745473      PMCID： PMC6856468          DOI： 10.1002/mdc3.12825

Source DB:  PubMed          Journal:  Mov Disord Clin Pract        ISSN： 2330-1619


  13 in total

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4.  Atypical multiple system atrophy is a new subtype of frontotemporal lobar degeneration: frontotemporal lobar degeneration associated with α-synuclein.

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Review 7.  Multiple system atrophy: pathogenic mechanisms and biomarkers.

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Authors:  S Gilman; G K Wenning; P A Low; D J Brooks; C J Mathias; J Q Trojanowski; N W Wood; C Colosimo; A Dürr; C J Fowler; H Kaufmann; T Klockgether; A Lees; W Poewe; N Quinn; T Revesz; D Robertson; P Sandroni; K Seppi; M Vidailhet
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9.  Photophobia, visual hallucinations, and REM sleep behavior disorder in progressive supranuclear palsy and corticobasal degeneration: a prospective study.

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Authors:  Shunsuke Koga; Naoya Aoki; Ryan J Uitti; Jay A van Gerpen; William P Cheshire; Keith A Josephs; Zbigniew K Wszolek; J William Langston; Dennis W Dickson
Journal:  Neurology       Date:  2015-07-02       Impact factor: 9.910
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  3 in total

1.  Reply to Comment on: A 57-Year-Old Woman With Progressive Left Hand Clumsiness and Falls.

Authors:  Vijayashankar Paramanandam; Diana Angelika Olszewska; Bhattacharjee Shakya; Albi Jose Chalissery; Martin O'Connell; Michael Farrell; Tim Lynch
Journal:  Mov Disord Clin Pract       Date:  2020-05-16

2.  Comment on: A 57-Year-Old Woman With Progressive Left Hand Clumsiness and Falls.

Authors:  Daniel Richter; Lars Tönges; Christos Krogias
Journal:  Mov Disord Clin Pract       Date:  2020-05-15

3.  Eye-of-the-Tiger Sign with an Unexpected Pathological Diagnosis.

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Journal:  Mov Disord Clin Pract       Date:  2021-11-07
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