Tanner C Jankins1, Ziyang Qin1, Keary M Engle1. 1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Abstract
This manuscript describes a modular method for preparing N-alkyl phosphinic amides from primary or secondary alcohols and primary phosphinic amide (R1R2P=ONH2) nucleophiles via transfer hydrogenation. The transformation typically proceeds in excellent yields, employs conveniently available reagents, and produces water as the only byproduct.
This manuscript describes a modular method for n class="Chemical">preparing N-alkyl phosphinic amides from primary or secondary alcohols and primary phosphinic amide (R1R2P=ONH2) nucleophiles via transfer hydrogenation. The transformation typically proceeds in excellent yields, employs conveniently available reagents, and produces water as the only byproduct.
Entities:
Keywords:
Amination; Phosphinic Amide; Phosphorous; Ruthenium; Transfer Hydrogenation
Authors: Kyle W Knouse; Justine N deGruyter; Michael A Schmidt; Bin Zheng; Julien C Vantourout; Cian Kingston; Stephen E Mercer; Ivar M Mcdonald; Richard E Olson; Ye Zhu; Chao Hang; Jason Zhu; Changxia Yuan; Qinggang Wang; Peter Park; Martin D Eastgate; Phil S Baran Journal: Science Date: 2018-08-02 Impact factor: 47.728