| Literature DB >> 31745236 |
Weida Meng1,2, Louise K Sjöholm3, Olga Kononenko4, Nicole Tay5, Dandan Zhang1,2, Daniil Sarkisyan4, Georgy Bakalkin4, Tomas J Ekström6, Joelle Rüegg7, Yun Liu8,9, Jennifer R Geske10, Alex Ing5, Wenqing Qiu1,2, Hiroyuki Watanabe4, Radwa Almamoun3, Helge Frieling11, Stefan Bleich11, Donghong Cui12, Joanna M Biernacka13, R Dayne Mayfield14, Yongjun Dang1, Victor M Karpyak13, Gunter Schumann5.
Abstract
Alcohol misuse is a major public health problem originating from genetic and environmental risk factors. Alterations in the brain epigenome may orchestrate changes in gene expression that lead to alcohol misuse and dependence. Through epigenome-wide association analysis of DNA methylation from human brain tissues, we identified a differentially methylated region, DMR-DLGAP2, associated with alcohol dependence. Methylation within DMR-DLGAP2 was found to be genotype-dependent, allele-specific and associated with reward processing in brain. Methylation at the DMR-DLGAP2 regulated expression of DLGAP2 in vitro, and Dlgap2-deficient mice showed reduced alcohol consumption compared with wild-type controls. These results suggest that DLGAP2 may be an interface for genetic and epigenetic factors controlling alcohol use and dependence.Entities:
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Year: 2019 PMID： 31745236 DOI： 10.1038/s41380-019-0588-9
Source DB: PubMed Journal: Mol Psychiatry ISSN： 1359-4184 Impact factor: 15.992