Vitri Widyaningsih1, Kenneth Rosenman, Mary Jo Reilly, Ling Wang, Dorothy R Pathak, Joseph C Gardiner, Carol Rice, Dimitri Monos, Milton Rossman. 1. Department of Public Health and Preventive Medicine, Universitas Sebelas Maret, Surakarta, Indonesia (Dr Widyaningsih); Department of Medicine (Dr Rosenman, Ms Reilly, Dr Wang); Department of Epidemiology and Biostatistics (Dr Pathak, Dr Gardiner), Michigan State University, East Lansing, Michigan; Department of Environmental Health, University of Cincinnati, Cincinnati (Dr Rice); Department of Pathology and Laboratory Medicine (Dr Monos); Department of Medicine (Dr Rossman), University of Pennsylvania, Philadelphia.
Abstract
OBJECTIVE: To evaluate interaction of HLA-DPβ1 and DRβ1 polymorphisms with metrics of beryllium exposure, in the development of beryllium sensitization (BeS) and chronic beryllium disease (CBD). METHODS: A matched case-control study of 61 CBD, 41 BeS, and 259 controls from two beryllium-processing facilities. RESULTS: BES and CBD were significantly associated with presence of DPβE69. Dose response of exposure was not observed for the development of BES and CBD with/without adjustment for DPβE69 (P > 0.05). The DRβE71 polymorphism was more common in BeS than CBD after adjusting for exposure and maybe a protective factor (aOR 0.4, 95% CI 0.2 to 0.9) against the progression of BeS to CBD. CONCLUSION: No exposure-response association was found, which may reflect that the workers in this high exposure cohort were above a threshold level where an exposure-response could be observed.
OBJECTIVE: To evaluate interaction of HLA-DPβ1 and DRβ1 polymorphisms with metrics of beryllium exposure, in the development of beryllium sensitization (BeS) and chronic beryllium disease (CBD). METHODS: A matched case-control study of 61 CBD, 41 BeS, and 259 controls from two beryllium-processing facilities. RESULTS: BES and CBD were significantly associated with presence of DPβE69. Dose response of exposure was not observed for the development of BES and CBD with/without adjustment for DPβE69 (P > 0.05). The DRβE71 polymorphism was more common in BeS than CBD after adjusting for exposure and maybe a protective factor (aOR 0.4, 95% CI 0.2 to 0.9) against the progression of BeS to CBD. CONCLUSION: No exposure-response association was found, which may reflect that the workers in this high exposure cohort were above a threshold level where an exposure-response could be observed.
Authors: James Crooks; Margaret M Mroz; Michael VanDyke; Alison McGrath; Christine Schuler; Erin C McCanlies; M Abbas Virji; Kenneth D Rosenman; Milton Rossman; Carol Rice; Dimitri Monos; Tasha E Fingerlin; Lisa A Maier Journal: Occup Environ Med Date: 2021-09-17 Impact factor: 4.402