Literature DB >> 31742088

Use of Aloe Vera and Turmeric Paste as a Supplementary Medicine in Oral Submucosal Fibrosis: A Pilot Study.

Vishwambhar Singh1, Utkarsh Agrawal1, Epibeni L Humtsoe1, Yanish Bhashkar Seetohul1.   

Abstract

Oral submucosal fibrosis is the major health issue affecting 2.5 million Indian population under the age of 40 years. All the available treatments give only symptomatic relief which is short lived.The incidence of Oral submucosal fibrosis still rising alarmingly and there is a dire need to search for an effective and safe remedy because of lack of present therapies to either provide a complete cure or treating the patients at the cost of adverse effects. A total of 140 clinically diagnosed patients with Oral submucosal fibrosis (diagnosed on the basis of reduction in interincisal distance on maximum mouth opening and palpable fibrous bands involving oral mucosa) within the age range of 18-50 years with decreased interincisal opening were selected (time period 1.5 year). These patients were given Inj. Triamcinolone (40 mg) and Inj Hyaluronidase every 21 days. Pt was divided in 2 groups (each containing both males and females) those receiving Triamcinolone ointment alone BD (control) and those receiving Triamcinolone ointment BD along with turmeric & aloe vera paste combination (test). A statistically significant improvement was seen in both burning sensation and mouth opening in both males and females. The result of the study shows that the synergistic action of these herbs results in higher efficacy and highly potent Oral submucosal fibrosis treatment. © Association of Otolaryngologists of India 2019.

Entities:  

Keywords:  Aloe vera; Hyaluronidase; Interincisal distance; Oral submucosal fibrosis; Triamcinolone

Year:  2019        PMID: 31742088      PMCID: PMC6848674          DOI: 10.1007/s12070-019-01599-w

Source DB:  PubMed          Journal:  Indian J Otolaryngol Head Neck Surg        ISSN: 2231-3796


  11 in total

Review 1.  Proposed clinical classification for oral submucous fibrosis.

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Review 2.  Aloe vera gel: update for dentistry.

Authors:  Richard L Wynn
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3.  Antibacterial action of curcumin and related compounds.

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Authors:  Saba Khan; Laxmikanth Chatra; Shenai K Prashanth; K M Veena; Prasanna Kumar Rao
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5.  Oral submucous fibrosis.

Authors:  J J Pindborg; S M Sirsat
Journal:  Oral Surg Oral Med Oral Pathol       Date:  1966-12

Review 6.  Discovery of curcumin, a component of golden spice, and its miraculous biological activities.

Authors:  Subash C Gupta; Sridevi Patchva; Wonil Koh; Bharat B Aggarwal
Journal:  Clin Exp Pharmacol Physiol       Date:  2012-03       Impact factor: 2.557

7.  Evaluation of the effect of newer antioxidant lycopene in the treatment of oral submucous fibrosis.

Authors:  Tapasya Vaibhav Karemore; Mukta Motwani
Journal:  Indian J Dent Res       Date:  2012 Jul-Aug

8.  Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis.

Authors:  Sarwar Alam; Iqbal Ali; K Y Giri; S Gokkulakrishnan; Subodh S Natu; Mohammad Faisal; Anshita Agarwal; Himanshu Sharma
Journal:  Oral Surg Oral Med Oral Pathol Oral Radiol       Date:  2013-12

Review 9.  Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.

Authors:  Bharat B Aggarwal; Bokyung Sung
Journal:  Trends Pharmacol Sci       Date:  2008-12-26       Impact factor: 14.819

10.  Pathogenesis and therapeutic intervention of oral submucous fibrosis.

Authors:  Thukanaykanpalayam Ragunathan Yoithapprabhunath; Thangadurai Maheswaran; Janardhanam Dineshshankar; Abraham Anusushanth; Pandian Sindhuja; Govindasamy Sitra
Journal:  J Pharm Bioallied Sci       Date:  2013-06
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