| Literature DB >> 31741929 |
Yusuke Azami1, Yuichiro Hayashi1,2, Tatsuya Nakamura1, Kanako Kimura1, Hisashi Yamaguchi1, Takashi Ono1, Kanako Takayama2, Katsumi Hirose1, Tomonori Yabuuchi1, Motohisa Suzuki1, Yoshiomi Hatayama1, Masato Hareyama1, Yasuhiro Kikuchi1, Nobukazu Fuwa3.
Abstract
The aim of this study was to evaluate the efficacy and safety of proton beam therapy for patients with locally recurrent parotid cancer. Between 2009 and 2012, ten patients with locally recurrent parotid gland cancer were treated with proton beam therapy (70.2 Gy equivalents in 32 fractions) with or without intra-arterial infusion chemotherapy of cisplatin (50 mg/body/week, for a total of 5-8 weeks). The median follow-up was 24 months (range 10-49 months). The 1-year overall survival and local control rates were 80 %, and the 3-year overall survival and local control rates were 60 %. None of the patients experienced grade 3-5 toxicities in the treatment or the follow-up periods. These findings suggest that proton beam therapy could be applied effectively and safely for patients with locally recurrent parotid gland cancer. © Association of Otolaryngologists of India 2016.Entities:
Keywords: Intra-arterial chemotherapy; Local recurrence; Parotid gland cancer; Proton beam therapy; Re-irradiation
Year: 2016 PMID： 31741929 PMCID： PMC6848668 DOI： 10.1007/s12070-016-1008-y
Source DB: PubMed Journal: Indian J Otolaryngol Head Neck Surg ISSN： 2231-3796