Maura Miccò1, Martina Sbarra1,2, Benedetta Gui1, Nicola Carlo Bianco1,2, Elena Rodolfino1, Riccardo Manfredi1,2. 1. Radiologia Diagnostica e Interventistica Generale, Area Diagnostica per Immagini, Dipartimento Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. 2. Istituto di Radiologia, Università Cattolica del Sacro Cuore, Rome, Italy.
Abstract
OBJECTIVE: To evaluate computed tomography (CT) findings able to predict outcome in patients with ovarian cancer (OC) and concomitant bowel occlusion. METHODS: This institutional review board-approved retrospective study included 31 patients with OC and clinical evidence of bowel occlusion who underwent CT at presentation between February 2013 and June 2015. Two radiologists recorded various qualitative CT features. Correlations between CT and survival data were made with Mann-Whitney test, Wilcoxon test, and χ2 test, as appropriate. Receiver operating characteristic curves were generated for statistically significant CT findings using logistic regression model. RESULTS: Two of 31 patients (6.5%) were alive at the end of this study; 29 patients (93.5%) died of disease. Median overall survival was 90 days. CT features associated with short life expectancy were bowel mural thinning (p=0.03), mesenteric tumor deposits (p=0.009), mesenteric infiltration (p=0.02), and ascites (p=0.04). Area under the curve was 0.728 (p=0.03) for mesenteric tumor deposits in predicting malignant bowel obstruction. CONCLUSIONS: Accurate interpretation of CT features may guide decisions in care of women with OC and bowel obstruction.
OBJECTIVE: To evaluate computed tomography (CT) findings able to predict outcome in patients with ovarian cancer (OC) and concomitant bowel occlusion. METHODS: This institutional review board-approved retrospective study included 31 patients with OC and clinical evidence of bowel occlusion who underwent CT at presentation between February 2013 and June 2015. Two radiologists recorded various qualitative CT features. Correlations between CT and survival data were made with Mann-Whitney test, Wilcoxon test, and χ2 test, as appropriate. Receiver operating characteristic curves were generated for statistically significant CT findings using logistic regression model. RESULTS: Two of 31 patients (6.5%) were alive at the end of this study; 29 patients (93.5%) died of disease. Median overall survival was 90 days. CT features associated with short life expectancy were bowel mural thinning (p=0.03), mesenteric tumor deposits (p=0.009), mesenteric infiltration (p=0.02), and ascites (p=0.04). Area under the curve was 0.728 (p=0.03) for mesenteric tumor deposits in predicting malignant bowel obstruction. CONCLUSIONS: Accurate interpretation of CT features may guide decisions in care of women with OC and bowel obstruction.
Entities:
Keywords:
Malignant bowel obstruction; computed tomography; ovarian cancer; personalized medicine
Authors: Claudio Lodoli; Marcello Covino; Miriam Attalla El Halabieh; Francesco Santullo; Andrea Di Giorgio; Carlo Abatini; Stefano Rotolo; Elena Rodolfino; Francesco Giovinazzo; Anna Fagotti; Giovanni Scambia; Francesco Franceschi; Fabio Pacelli Journal: Front Surg Date: 2021-11-26