| Literature DB >> 31738087 |
Xiao-Na Jia1, Jin-Lian Zhao1, Jia-Min Feng1, Ri-Dao Chen1, Ke-Bo Xie1, Da-Wei Chen1, Yan Li1, Ji-Mei Liu1, Jun-Gui Dai1.
Abstract
Bistachybotrysin K (1), one new phenylspirodrimane dimer with a central 6/7 oxygen heterocycle core, was isolated from the fungus Stachybotrys chartarum CGMCC 3.5365. Its structure was elucidated by extensive spectroscopic data and single-crystal X-ray diffraction. Compound 1 showed significant cytotoxicity against human tumor cell lines HCT116, NCI-H460, BGC823, Daoy, and HepG2 with IC50 values in the range of 1.1-4.7 µM.Entities:
Keywords: Bistachybotrysin; Stachybotrys chartarum; cytotoxicity; phenylspirodrimane dimer
Year: 2019 PMID： 31738087 DOI： 10.1080/10286020.2019.1680645
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569