Hee Jung Kim1, Seong Cheol Jeong2, Jae Seung Jung1, In Seup Kim2, Choon-Hak Lim3, Ho Sung Son1. 1. Department of Thoracic and Cardiovascular Surgery, Korea University Anam Hospital, College of Medicine, Korea University, Seoul, Korea. 2. Department of Thoracic and Cardiovascular Surgery, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Uijeongbu, Korea. 3. Department of Anesthesiology and Pain Medicine, Korea University Anam Hospital, College of Medicine, Korea University, Seoul, Korea.
Abstract
BACKGROUND: Whether arterial return cannula position affects the kidney during Veno-Arterial extracorporeal membrane oxygenation (ECMO) is unclear. Therefore, we compared hemodynamic parameters and acute kidney injury (AKI) biomarkers between ascending aorta return (aECMO) and femoral artery return ECMO (fECMO) in swine to evaluate the effect of cannula position on the kidney. METHODS: A total of twelve swines were allocated randomly into two groups. ECMO was maintained for 6h. Hemodynamic parameters including mean arterial pressure (MAP), renal arterial flow rate (AF), energy equivalent pressure (EEP), and surplus hemodynamic energy (SHE) were measured at the left renal artery. For evaluation of kidney injury, samples were obtained for blood urea nitrogen, creatinine, cystatin C, and neutrophil gelatinase-associated lipocalin (before ECMO, and 1, 3, and 6 h after initiating ECMO). RESULTS: Before the start of ECMO, hemodynamic parameters were not different between the two groups. With regard to the rate of change before and after ECMO, the fECMO group showed a significantly higher increase in MAP, AF, and EEP and a greater decrease in SHE than the aECMO group (P<0.001). In inter-group analysis, no significant difference in time-dependent trends were observed for biochemical laboratory levels. CONCLUSIONS: fECMO support was associated with a higher energy profile at the renal artery than that with aECMO, whereas pulsatility was decreased. 2019 Journal of Thoracic Disease. All rights reserved.
BACKGROUND: Whether arterial return cannula position affects the kidney during Veno-Arterial extracorporeal membrane oxygenation (ECMO) is unclear. Therefore, we compared hemodynamic parameters and acute kidney injury (AKI) biomarkers between ascending aorta return (aECMO) and femoral artery return ECMO (fECMO) in swine to evaluate the effect of cannula position on the kidney. METHODS: A total of twelve swines were allocated randomly into two groups. ECMO was maintained for 6h. Hemodynamic parameters including mean arterial pressure (MAP), renal arterial flow rate (AF), energy equivalent pressure (EEP), and surplus hemodynamic energy (SHE) were measured at the left renal artery. For evaluation of kidney injury, samples were obtained for blood urea nitrogen, creatinine, cystatin C, and neutrophil gelatinase-associated lipocalin (before ECMO, and 1, 3, and 6 h after initiating ECMO). RESULTS: Before the start of ECMO, hemodynamic parameters were not different between the two groups. With regard to the rate of change before and after ECMO, the fECMO group showed a significantly higher increase in MAP, AF, and EEP and a greater decrease in SHE than the aECMO group (P<0.001). In inter-group analysis, no significant difference in time-dependent trends were observed for biochemical laboratory levels. CONCLUSIONS: fECMO support was associated with a higher energy profile at the renal artery than that with aECMO, whereas pulsatility was decreased. 2019 Journal of Thoracic Disease. All rights reserved.
Authors: Antonio Loforte; Giuseppe Marinelli; Francesco Musumeci; Gianluca Folesani; Emanuele Pilato; Sofia Martin Suarez; Andrea Montalto; Paola Lilla Della Monica; Francesco Grigioni; Guido Frascaroli; Antonio Menichetti; Roberto Di Bartolomeo; Giorgio Arpesella Journal: Artif Organs Date: 2014-05-20 Impact factor: 3.094
Authors: Faeq Husain-Syed; Zaccaria Ricci; Daniel Brodie; Jean-Louis Vincent; V Marco Ranieri; Arthur S Slutsky; Fabio Silvio Taccone; Luciano Gattinoni; Claudio Ronco Journal: Intensive Care Med Date: 2018-07-24 Impact factor: 17.440