Corrigendum: The Spectrum of SPTA1-Associated Hereditary Spherocytosis.

[This corrects the article DOI: 10.3389/fphys.2019.00815.].

In the original article, there was a mistake in Table 1 as published. The SPTA1 mutation of Allele 2 in Patient 1, is stated as “c.4294T>A (p.L1432*).” The correct mutation should read “c.4295del (p.L1432*).” The corrected Table 1 appears below.

Table 1

Genetic mutations and associated phenotype in HS due to SPTA1 mutations.

Phenotype	Patient	Allele 1	Allele 2	Age at time of report and comments	Ektacytometry	α-spectrin in RBC ghosts (% of control)
GROUP I (patients 1–4) Severe, recessive HS (transfusion-dependent, responding to splenectomy)	1	c.4339-99C > T	c.4295del (p.L1432*)	11 year-old, chronic transfusion requirement with partial response to partial splenectomy, resolved after total splenectomy		54%
	2	c.4339-99C > T	c.5102A > T (p.L1701*)	7 year-old, chronic transfusion requirement, improved with partial splenectomy		64%
	3	c.4339-99C > T	c.3267A > T (p.Y1089*)	11 year-old, not splenectomized due to family preference, continues to require frequent transfusions	Not evaluable in a transfused sample
	4	Mutation not identified	Gross deletion of SPTA1	3.5 year-old, RT-PCR demonstrated significantly decreased α-spectrin expression; hemoglobin has normalized after recent splenectomy	Not evaluable in a transfused sample
GROUP II (patients 5–8) Severe to moderately severe, recessive HS	5	c.4339-99C > T	c.1120C > T (p.R374*)	4 year-old, chronic transfusion requirement for first three years with improved pattern since.	Sample not provided after age 3, when transfusion-independent
	6	c.4339-99C > T	c.1351-1G > T	7 year-old, occasional transfusion requirement, resolved after splenectomy at 5 years of age		59%
	7	c.4339-99C>T	c.2671C > T (p.R891*)	4 year-old, has not been transfused so far, Hgb 7.1-8.9 g/dL, ARC 420-572 x 103/μl.		61%
	8	c.4339-99C > T	c.3257delT	8 year-old, transfused once as neonate, Hgb 10.6–11.8 g/dL, ARC 354–535 x 103/μl; now Hgb 15–16 g/dL with normal ARC after splenectomy at 6 years of age (splenectomy performed because of chronic abdominal pain due to co-morbidities)		Not performed.
GROUP III (patients 9-11) Life-threatening anemia in utero leading to fatal hydrops fetalis if untreated (transfusion-dependent, not responding to splenectomy)	9	c.4206delG (fs)	c.4180delT (fs) in haplotype with c.6631C > T (p.R2211C)	Died at birth. Post-mortem diagnosis from parental studies and DNA extracted from liver tissue saved in paraffin block	N/A
	10	c.6788+11C > T	c.6788+11C > T	11 year-old, born prematurely at EGA of 33 weeks with hydrops fetalis, remained transfusion-dependent even after splenectomy; now doing well after matched sibling transplant	Not evaluable in a transfused sample (required chronic transfusions up until bone marrow transplant)	26% (performed in CD71+ cells)
	11	c.6154del (p.Ala2052fs)	c.6154del (p.Ala2052fs)	2 year-old, severe in-utero anemia requiring five in-utero transfusions. Born with severe neonatal hyperbilirubinemia requiring exchange transfusion. Remains transfusion-dependent	Not evaluable in a transfused sample

Of note, all the SPTA1 variants reported here except c.4339-99C > T (αLEPRA) and c.2671C > T; p.R891

(Bogardus et al., .

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.