Artur Pałasz1, Marta Tyszkiewicz-Nwafor2, Aleksandra Suszka-Świtek1, Flora Bacopoulou3, Monika Dmitrzak-Węglarz4, Agata Dutkiewicz2, Agnieszka Słopień2, Małgorzata Janas-Kozik5, Krzysztof M Wilczyński5, Łukasz Filipczyk1, Katarzyna Bogus1, Ewa Rojczyk6, Elżbieta Paszyńska7, Ryszard Wiaderkiewicz1. 1. Department of Histology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland. 2. Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland. 3. First Department of Pediatrics, Center for Adolescent Medicine and UNESCO Chair on Adolescent Health Care, School of Medicine, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, Athens, Greece. 4. Department of Psychiatry, Poznan University of Medical Sciences, Psychiatric Genetics Unit, Poznan, Poland. 5. Department of Psychiatry and Psychotherapy, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland. 6. Department of Descriptive and Topographic Anatomy, School of Medicine with Division of Dentistry in Zabrze, Medical University of Silesia Zabrze, Poland. 7. Department of Integrated Dentistry, Faculty of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, Poznan, Poland.
Abstract
OBJECTIVES: It is hypothesized that novel neuropeptides such as phoenixin (PNX), spexin (SPX), and kisspeptin (KISS) are involved in the pathogenesis of eating disorders. The study presented here analyzed neuropeptide concentrations during the course of anorexia nervosa (AN) and aimed to correlate those values with anthropometric and psychometric measurements. METHODS: A longitudinal study was carried outin 30 AN adolescent patients and 15 age-matched healthy female controls. Selected neuroprotein serum levels were analyzed in malnourished patients (accAN) and following partial weight recovery (norAN), and these values were compared with the control group. RESULTS: In accAN patients, decreased serum PNX levels were detected while SPX serum concentrations were lower in the accAN and norAN patients. No differences were observed in KISS concentrations in all studied groups. CONCLUSIONS: In malnourished adolescent inpatients with AN, serum PNX and SPX level were decreased. The partial weight recovery normalized PNX concentrations but failed to normalize SPX levels. Therefore these two neuropeptides might be crucial for the etiology and course of the AN. The KISS levels did not change in the course of AN. The PNX levels were associated with some symptoms of eating disorders which may indicate its potential contribution in the regulation of emotions and behaviors in AN.
OBJECTIVES: It is hypothesized that novel neuropeptides such as phoenixin (PNX), spexin (SPX), and kisspeptin (KISS) are involved in the pathogenesis of eating disorders. The study presented here analyzed neuropeptide concentrations during the course of anorexia nervosa (AN) and aimed to correlate those values with anthropometric and psychometric measurements. METHODS: A longitudinal study was carried outin 30 AN adolescent patients and 15 age-matched healthy female controls. Selected neuroprotein serum levels were analyzed in malnourished patients (accAN) and following partial weight recovery (norAN), and these values were compared with the control group. RESULTS: In accAN patients, decreased serum PNX levels were detected while SPX serum concentrations were lower in the accAN and norAN patients. No differences were observed in KISS concentrations in all studied groups. CONCLUSIONS: In malnourished adolescent inpatients with AN, serum PNX and SPX level were decreased. The partial weight recovery normalized PNX concentrations but failed to normalize SPX levels. Therefore these two neuropeptides might be crucial for the etiology and course of the AN. The KISS levels did not change in the course of AN. The PNX levels were associated with some symptoms of eating disorders which may indicate its potential contribution in the regulation of emotions and behaviors in AN.
Authors: Marta Tyszkiewicz-Nwafor; Filip Rybakowski; Monika Dmitrzak-Weglarz; Maria Skibinska; Elżbieta Paszynska; Agata Dutkiewicz; Agnieszka Słopien Journal: Front Psychiatry Date: 2020-02-28 Impact factor: 4.157
Authors: Matthew K H Wong; Mulan He; Kong Hung Sze; Tao Huang; Wendy K W Ko; Zhao-Xiang Bian; Anderson O L Wong Journal: Front Endocrinol (Lausanne) Date: 2021-07-02 Impact factor: 5.555
Authors: Matthew K H Wong; Yuan Chen; Mulan He; Chengyuan Lin; Zhaoxiang Bian; Anderson O L Wong Journal: Front Endocrinol (Lausanne) Date: 2021-07-02 Impact factor: 5.555