| Literature DB >> 31736224 |
Ara A Salibian1, Jonathan M Bekisz1, Jordan D Frey1, Brooke Miller1, Mihye Choi1, Nolan S Karp1.
Abstract
Bilateral prophylactic mastectomies (BPM) in young previvors with high-risk mutations are rising; however, little data on management, therapy timing, and outcomes exist. BRCA+ patients under 30 undergoing BPM from 2006 to 2018 were reviewed. Twenty-two patients aged 23-29 underwent mastectomy 4.2 years after genetic diagnosis. Twelve patients completed surveys, most often citing personal decisions (50%) for undergoing mastectomy and plastic surgeons' recommendations (83.3%) for reconstruction. About 73% of patients completely understood risks/benefits of mastectomy and 63.6% of reconstruction. Patients reported high BREAST-Q Satisfaction and Well-Being scores. Continued educational resource development will optimize shared decision-making in the reconstructive process.Entities:
Keywords: BRCA; nipple-sparing mastectomy; previvor; quality-of-life
Mesh:
Year: 2019 PMID: 31736224 DOI: 10.1111/tbj.13692
Source DB: PubMed Journal: Breast J ISSN: 1075-122X Impact factor: 2.431