Literature DB >> 31735991

Update 2020: nomenclature and listing of celiac disease-relevant gluten epitopes recognized by CD4+ T cells.

Ludvig M Sollid1, Jason A Tye-Din2, Shuo-Wang Qiao3, Robert P Anderson2, Carmen Gianfrani4, Frits Koning5.   

Abstract

Celiac disease is caused by an abnormal intestinal T cell response to cereal gluten proteins. The disease has a strong human leukocyte antigen (HLA) association, and CD4+ T cells recognizing gluten epitopes presented by disease-associated HLA-DQ allotypes are considered to be drivers of the disease. This paper provides an update of the currently known HLA-DQ restricted gluten T cell epitopes with their names and sequences.

Entities:  

Keywords:  Celiac disease; Epitopes; Gluten; HLA-DQ2; HLA-DQ8; T cell

Mesh：

Substances：

Year:  2019        PMID： 31735991     DOI： 10.1007/s00251-019-01141-w

Source DB:  PubMed          Journal:  Immunogenetics        ISSN： 0093-7711            Impact factor:   2.846


  26 in total

1.  Glutenin is involved in the gluten-driven mucosal T cell response.

Authors:  Y van de Wal; Y M Kooy; P van Veelen; W Vader; S A August; J W Drijfhout; S A Peña; F Koning
Journal:  Eur J Immunol       Date:  1999-10       Impact factor: 5.532

2.  Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimer.

Authors:  Yvonne Kooy-Winkelaar; Menno van Lummel; Antonis K Moustakas; Joachim Schweizer; M Luisa Mearin; Chris J Mulder; Bart O Roep; Jan W Drijfhout; George K Papadopoulos; Jeroen van Bergen; Frits Koning
Journal:  J Immunol       Date:  2011-10-17       Impact factor: 5.422

3.  Gliadin-reactive T cells in Italian children from preventCD cohort at high risk of celiac disease.

Authors:  Alessandra Camarca; Renata Auricchio; Stefania Picascia; Olga Fierro; Mariantonia Maglio; Erasmo Miele; Basilio Malamisura; Luigi Greco; Riccardo Troncone; Carmen Gianfrani
Journal:  Pediatr Allergy Immunol       Date:  2017-06       Impact factor: 6.377

4.  Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation.

Authors:  Shuo-Wang Qiao; Elin Bergseng; Oyvind Molberg; Günther Jung; Burkhard Fleckenstein; Ludvig M Sollid
Journal:  J Immunol       Date:  2005-07-01       Impact factor: 5.422

5.  Effective shutdown in the expression of celiac disease-related wheat gliadin T-cell epitopes by RNA interference.

Authors:  Javier Gil-Humanes; Fernando Pistón; Stig Tollefsen; Ludvig M Sollid; Francisco Barro
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-09       Impact factor: 11.205

6.  Two novel HLA-DQ2.5-restricted gluten T cell epitopes in the DQ2.5-glia-γ4 epitope family.

Authors:  Shuo-Wang Qiao; Ludvig M Sollid
Journal:  Immunogenetics       Date:  2019-11-01       Impact factor: 2.846

7.  Shifting the limits in wheat research and breeding using a fully annotated reference genome.

Authors: 
Journal:  Science       Date:  2018-08-16       Impact factor: 47.728

Review 8.  Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules.

Authors:  Ludvig M Sollid; Shuo-Wang Qiao; Robert P Anderson; Carmen Gianfrani; Frits Koning
Journal:  Immunogenetics       Date:  2012-02-10       Impact factor: 2.846

9.  The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase.

Authors:  H Arentz-Hansen; R Körner; O Molberg; H Quarsten; W Vader; Y M Kooy; K E Lundin; F Koning; P Roepstorff; L M Sollid; S N McAdam
Journal:  J Exp Med       Date:  2000-02-21       Impact factor: 14.307

10.  Outlook for coeliac disease patients: towards bread wheat with hypoimmunogenic gluten by gene editing of α- and γ-gliadin gene families.

Authors:  Aurélie Jouanin; Jan G Schaart; Lesley A Boyd; James Cockram; Fiona J Leigh; Ruth Bates; Emma J Wallington; Richard G F Visser; Marinus J M Smulders
Journal:  BMC Plant Biol       Date:  2019-08-01       Impact factor: 4.215
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  34 in total

1.  Immunogenetics special issue 2020: nomenclature, databases, and bioinformatics in immunogenetics.

Authors:  Can Kesmir; Ronald Bontrop
Journal:  Immunogenetics       Date:  2020-02       Impact factor: 2.846

2.  Hydroxychloroquine inhibits the mitochondrial antioxidant system in activated T cells.

Authors:  Man Lyang Kim; Melinda Y Hardy; Laura E Edgington-Mitchell; Sri H Ramarathinam; Shan Zou Chung; Amy K Russell; Iain Currie; Brad E Sleebs; Anthony W Purcell; Jason A Tye-Din; Ian P Wicks
Journal:  iScience       Date:  2021-11-25

Review 3.  Single-cell approaches to dissect adaptive immune responses involved in autoimmunity: the case of celiac disease.

Authors:  Ida Lindeman; Ludvig M Sollid
Journal:  Mucosal Immunol       Date:  2021-09-16       Impact factor: 7.313

4.  The mosaic oat genome gives insights into a uniquely healthy cereal crop.

Authors:  Nadia Kamal; Nikos Tsardakas Renhuldt; Johan Bentzer; Heidrun Gundlach; Georg Haberer; Angéla Juhász; Thomas Lux; Utpal Bose; Jason A Tye-Din; Daniel Lang; Nico van Gessel; Ralf Reski; Yong-Bi Fu; Peter Spégel; Alf Ceplitis; Axel Himmelbach; Amanda J Waters; Wubishet A Bekele; Michelle L Colgrave; Mats Hansson; Nils Stein; Klaus F X Mayer; Eric N Jellen; Peter J Maughan; Nicholas A Tinker; Martin Mascher; Olof Olsson; Manuel Spannagl; Nick Sirijovski
Journal:  Nature       Date:  2022-05-18       Impact factor: 69.504

Review 5.  Current and emerging therapies for coeliac disease.

Authors:  Laura Kivelä; Alberto Caminero; Daniel A Leffler; Maria Ines Pinto-Sanchez; Jason A Tye-Din; Katri Lindfors
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2020-11-20       Impact factor: 46.802

6.  Whole blood interleukin-2 release test to detect and characterize rare circulating gluten-specific T cell responses in coeliac disease.

Authors:  R P Anderson; G Goel; M Y Hardy; A K Russell; S Wang; E Szymczak; R Zhang; K E Goldstein; K Neff; K E Truitt; L J Williams; J L Dzuris; J A Tye-Din
Journal:  Clin Exp Immunol       Date:  2021-02-28       Impact factor: 5.732

7.  A Sensitive Whole Blood Assay Detects Antigen-Stimulated Cytokine Release From CD4+ T Cells and Facilitates Immunomonitoring in a Phase 2 Clinical Trial of Nexvax2 in Coeliac Disease.

Authors:  Melinda Y Hardy; Gautam Goel; Amy K Russell; Swee Lin G Chen Yi Mei; Gregor J E Brown; Suyue Wang; Evan Szymczak; Ruan Zhang; Kaela E Goldstein; Kristin M Neff; Leslie J Williams; Kenneth E Truitt; John L Dzuris; Jason A Tye-Din; Robert P Anderson
Journal:  Front Immunol       Date:  2021-05-19       Impact factor: 7.561

8.  Thermal and Acidic Treatments of Gluten Epitopes Affect Their Recognition by HLA-DQ2 in silico.

Authors:  Jihui Gao; Haolan Du; Zekun Zhou; Zhongxin Liang; Hongrui Liang; PeiAo Zhang; Xue Wei; Shujun Liu; Linglin Fu; Yanbo Wang; Huilian Che; Wentong Xue; Fengjiao Xin; Dong Yang
Journal:  Front Nutr       Date:  2021-05-19

9.  Gamma-gliadin specific celiac disease antibodies recognize p31-43 and p57-68 alpha gliadin peptides in deamidation related manner as a result of cross-reaction.

Authors:  Ádám Diós; Rita Elek; Ildikó Szabó; Szilvia Horváth; Judit Gyimesi; Róbert Király; Katharina Werkstetter; Sibylle Koletzko; László Fésüs; Ilma R Korponay-Szabó
Journal:  Amino Acids       Date:  2021-05-31       Impact factor: 3.520

10.  A Case Study of the Response of Immunogenic Gluten Peptides to Sourdough Proteolysis.

Authors:  Olivia J Ogilvie; Juliet A Gerrard; Sarah Roberts; Kevin H Sutton; Nigel Larsen; Laura J Domigan
Journal:  Nutrients       Date:  2021-06-01       Impact factor: 5.717
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