Masoud Najafi1, Bagher Farhood2, Keywan Mortezaee3,4, Ebrahim Kharazinejad5, Jamal Majidpoor6, Reza Ahadi6. 1. Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran. 2. Departments of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran. 3. Cancer and Immunology Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran. Keywan987@yahoo.com. 4. Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. Keywan987@yahoo.com. 5. Department of Anatomy, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, Iran. 6. Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract
PURPOSE: Cancer stem cells (CSCs) are highly tumorigenic cell types that reside within specific areas of tumor microenvironment (TME), and are endowed with self-renewal and resistance properties. Here, we aimed to discuss mechanisms involved in hypoxia-derived CSC resistance and targeting for effective cancer therapy. RESULTS: Preferential localization within hypoxic niches would help CSCs develop adaptive mechanisms, mediated through the modification of responses to various stressors and, as a result, show a more aggressive behavior. CONCLUSION: Hypoxia, in fact, serves as a multi-tasking strategy to nurture CSCs with this adaptive capacity, complexing targeted therapies.
PURPOSE:Cancer stem cells (CSCs) are highly tumorigenic cell types that reside within specific areas of tumor microenvironment (TME), and are endowed with self-renewal and resistance properties. Here, we aimed to discuss mechanisms involved in hypoxia-derived CSC resistance and targeting for effective cancer therapy. RESULTS: Preferential localization within hypoxic niches would help CSCs develop adaptive mechanisms, mediated through the modification of responses to various stressors and, as a result, show a more aggressive behavior. CONCLUSION:Hypoxia, in fact, serves as a multi-tasking strategy to nurture CSCs with this adaptive capacity, complexing targeted therapies.
Authors: Alexander Pietras; Amanda M Katz; Elin J Ekström; Boyoung Wee; John J Halliday; Kenneth L Pitter; Jillian L Werbeck; Nduka M Amankulor; Jason T Huse; Eric C Holland Journal: Cell Stem Cell Date: 2014-03-06 Impact factor: 24.633
Authors: Klaas M Govaert; Benjamin L Emmink; Maarten W Nijkamp; Zing J Cheung; Ernst J A Steller; Szabolcs Fatrai; Menno T de Bruijn; Onno Kranenburg; Inne H M Borel Rinkes Journal: Ann Surg Date: 2014-04 Impact factor: 12.969
Authors: Alan McIntyre; Alzbeta Hulikova; Ioanna Ledaki; Cameron Snell; Dean Singleton; Graham Steers; Peter Seden; Dylan Jones; Esther Bridges; Simon Wigfield; Ji-Liang Li; Angela Russell; Pawel Swietach; Adrian L Harris Journal: Cancer Res Date: 2016-05-17 Impact factor: 12.701